Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus Erythematosus
Malondialdehyde (MDA) is a marker of oxidative stress and antioxidant status. Oxidative stress has been observed to be increased in systemic lupus erythematosus (SLE). Some studies have shown that MDA is upregulated in SLE compared to controls. However, the literature lacks reports regarding the rel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/8/1535 |
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| author | Nayra Merino de Paz María García-González Fuensanta Gómez-Bernal Juan C. Quevedo-Abeledo Antonia de Vera-González Raquel López-Mejias Pedro Abreu-González Candelaria Martín-González Miguel Á. González-Gay Iván Ferraz-Amaro |
| author_facet | Nayra Merino de Paz María García-González Fuensanta Gómez-Bernal Juan C. Quevedo-Abeledo Antonia de Vera-González Raquel López-Mejias Pedro Abreu-González Candelaria Martín-González Miguel Á. González-Gay Iván Ferraz-Amaro |
| author_sort | Nayra Merino de Paz |
| collection | DOAJ |
| description | Malondialdehyde (MDA) is a marker of oxidative stress and antioxidant status. Oxidative stress has been observed to be increased in systemic lupus erythematosus (SLE). Some studies have shown that MDA is upregulated in SLE compared to controls. However, the literature lacks reports regarding the relationship of MDA to disease manifestations. This is relevant since SLE is a multisystemic disease which may affect virtually any organ in the body. In this study, we set out to analyze how MDA serum levels are associated with disease expression in a large series of SLE patients who were fully characterized in clinical and laboratory terms. A total of 284 patients with SLE were recruited. Serum levels of MDA, and the activity (SLEDAI), severity (Katz) and damage index (SLICC-DI) scores, full lipid profile, and carotid subclinical atherosclerosis were assessed. In addition, a full characterization of the complement system was performed in SLE patients’ samples. Multivariable linear regression analysis was executed to study the relationship between clinical and laboratory disease characteristics and MDA. A statistically significant negative relationship was found between disease duration and MDA. In contrast, the presence of anti-nucleosome antibodies was positively associated with MDA. Regarding the SLICC-DI areas, both the musculoskeletal domain and the cutaneous domain were significantly related to higher serum MDA values. Furthermore, after adjustment for confounding factors, lower levels of the classical complement pathway, which denotes activation, were associated with higher serum levels of MDA. In conclusion, cumulative musculoskeletal and skin damage in SLE patients is associated with superior serum levels of MDA. In addition, activation of the complement system is also related to higher circulating MDA levels. |
| first_indexed | 2024-03-11T00:10:26Z |
| format | Article |
| id | doaj.art-5208ba6458154fa08ffbdb742aa35834 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T00:10:26Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-5208ba6458154fa08ffbdb742aa358342023-11-19T00:01:23ZengMDPI AGAntioxidants2076-39212023-07-01128153510.3390/antiox12081535Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus ErythematosusNayra Merino de Paz0María García-González1Fuensanta Gómez-Bernal2Juan C. Quevedo-Abeledo3Antonia de Vera-González4Raquel López-Mejias5Pedro Abreu-González6Candelaria Martín-González7Miguel Á. González-Gay8Iván Ferraz-Amaro9Division of Dermatology, Dermamedicin Clínicas, 38004 Santa Cruz de Tenerife, SpainDivision of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, SpainDivision of Central Laboratory, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, SpainDivision of Rheumatology, Hospital Doctor Negrín, 35010 Las Palmas de Gran Canaria, SpainDivision of Central Laboratory, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, 39011 Santander, SpainUnit of Physiology, Department of Basic Medical Sciences, University of La Laguna, 38200 Santa Cruz de Tenerife, SpainDivision of Internal Medicine, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, SpainDivision of Rheumatology, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDivision of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, SpainMalondialdehyde (MDA) is a marker of oxidative stress and antioxidant status. Oxidative stress has been observed to be increased in systemic lupus erythematosus (SLE). Some studies have shown that MDA is upregulated in SLE compared to controls. However, the literature lacks reports regarding the relationship of MDA to disease manifestations. This is relevant since SLE is a multisystemic disease which may affect virtually any organ in the body. In this study, we set out to analyze how MDA serum levels are associated with disease expression in a large series of SLE patients who were fully characterized in clinical and laboratory terms. A total of 284 patients with SLE were recruited. Serum levels of MDA, and the activity (SLEDAI), severity (Katz) and damage index (SLICC-DI) scores, full lipid profile, and carotid subclinical atherosclerosis were assessed. In addition, a full characterization of the complement system was performed in SLE patients’ samples. Multivariable linear regression analysis was executed to study the relationship between clinical and laboratory disease characteristics and MDA. A statistically significant negative relationship was found between disease duration and MDA. In contrast, the presence of anti-nucleosome antibodies was positively associated with MDA. Regarding the SLICC-DI areas, both the musculoskeletal domain and the cutaneous domain were significantly related to higher serum MDA values. Furthermore, after adjustment for confounding factors, lower levels of the classical complement pathway, which denotes activation, were associated with higher serum levels of MDA. In conclusion, cumulative musculoskeletal and skin damage in SLE patients is associated with superior serum levels of MDA. In addition, activation of the complement system is also related to higher circulating MDA levels.https://www.mdpi.com/2076-3921/12/8/1535malondialdehydesystemic lupus erythematosusdisease damagemusculoskeletal complicationscomplement system |
| spellingShingle | Nayra Merino de Paz María García-González Fuensanta Gómez-Bernal Juan C. Quevedo-Abeledo Antonia de Vera-González Raquel López-Mejias Pedro Abreu-González Candelaria Martín-González Miguel Á. González-Gay Iván Ferraz-Amaro Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus Erythematosus Antioxidants malondialdehyde systemic lupus erythematosus disease damage musculoskeletal complications complement system |
| title | Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus Erythematosus |
| title_full | Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus Erythematosus |
| title_fullStr | Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus Erythematosus |
| title_full_unstemmed | Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus Erythematosus |
| title_short | Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus Erythematosus |
| title_sort | relationship between malondialdehyde serum levels and disease features in a full characterized series of 284 patients with systemic lupus erythematosus |
| topic | malondialdehyde systemic lupus erythematosus disease damage musculoskeletal complications complement system |
| url | https://www.mdpi.com/2076-3921/12/8/1535 |
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