(Non)translational medicine: RNA-based therapeutics in bacteria
The rise and spread of antibiotic resistance is among the most severe challenges facing modern medicine. Despite this fact, attempts to develop novel classes of antibiotic have been largely unsuccessful. The traditional mechanisms by which antibiotics work are subject to relatively rapid bacterial r...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00230/full |
| _version_ | 1819011315654459392 |
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| author | Adam M Dinan Brendan J Loftus |
| author_facet | Adam M Dinan Brendan J Loftus |
| author_sort | Adam M Dinan |
| collection | DOAJ |
| description | The rise and spread of antibiotic resistance is among the most severe challenges facing modern medicine. Despite this fact, attempts to develop novel classes of antibiotic have been largely unsuccessful. The traditional mechanisms by which antibiotics work are subject to relatively rapid bacterial resistance via mutation, and hence have a limited period of efficacy. One promising strategy to ameliorate this problem is to shift from the use of chemical compounds targeting protein structures and processes to a new era of RNA-based therapeutics. RNA-mediated regulation (riboregulation) has evolved naturally in bacteria and is therefore a highly efficient means by which gene expression can be manipulated. Here, we describe recent advances towards the development of effective anti-bacterial therapies, which operate through various strategies centred on RNA. Significant challenges facing the field, including the identification of suitable molecular targets and delivery strategies, will also be considered. |
| first_indexed | 2024-12-21T01:26:12Z |
| format | Article |
| id | doaj.art-5209e195514646f085853531eb542d2d |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-21T01:26:12Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-5209e195514646f085853531eb542d2d2022-12-21T19:20:30ZengFrontiers Media S.A.Frontiers in Genetics1664-80212013-11-01410.3389/fgene.2013.0023066621(Non)translational medicine: RNA-based therapeutics in bacteriaAdam M Dinan0Brendan J Loftus1University College DublinUniversity College DublinThe rise and spread of antibiotic resistance is among the most severe challenges facing modern medicine. Despite this fact, attempts to develop novel classes of antibiotic have been largely unsuccessful. The traditional mechanisms by which antibiotics work are subject to relatively rapid bacterial resistance via mutation, and hence have a limited period of efficacy. One promising strategy to ameliorate this problem is to shift from the use of chemical compounds targeting protein structures and processes to a new era of RNA-based therapeutics. RNA-mediated regulation (riboregulation) has evolved naturally in bacteria and is therefore a highly efficient means by which gene expression can be manipulated. Here, we describe recent advances towards the development of effective anti-bacterial therapies, which operate through various strategies centred on RNA. Significant challenges facing the field, including the identification of suitable molecular targets and delivery strategies, will also be considered.http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00230/fullBacteriaPeptide Nucleic AcidsRiboswitchsmall RNAantibiotic resistanceantisense |
| spellingShingle | Adam M Dinan Brendan J Loftus (Non)translational medicine: RNA-based therapeutics in bacteria Frontiers in Genetics Bacteria Peptide Nucleic Acids Riboswitch small RNA antibiotic resistance antisense |
| title | (Non)translational medicine: RNA-based therapeutics in bacteria |
| title_full | (Non)translational medicine: RNA-based therapeutics in bacteria |
| title_fullStr | (Non)translational medicine: RNA-based therapeutics in bacteria |
| title_full_unstemmed | (Non)translational medicine: RNA-based therapeutics in bacteria |
| title_short | (Non)translational medicine: RNA-based therapeutics in bacteria |
| title_sort | non translational medicine rna based therapeutics in bacteria |
| topic | Bacteria Peptide Nucleic Acids Riboswitch small RNA antibiotic resistance antisense |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00230/full |
| work_keys_str_mv | AT adammdinan nontranslationalmedicinernabasedtherapeuticsinbacteria AT brendanjloftus nontranslationalmedicinernabasedtherapeuticsinbacteria |