Primary squamous cell carcinoma of the breast: a case report
Abstract Introduction Squamous cell carcinoma (SCC) of the breast is a rare variant of invasive breast cancer that has been classified as metaplastic carcinoma. When a tumor is composed of spindle cells, diagnosis is challenging. Case report A 42-year-old woman with a large mass in the right breast...
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| Format: | Article |
| Language: | English |
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Springer
2024-04-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-024-00958-6 |
| _version_ | 1797219728977035264 |
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| author | Xibo Liu Jiahui Chen Chuanling Hou |
| author_facet | Xibo Liu Jiahui Chen Chuanling Hou |
| author_sort | Xibo Liu |
| collection | DOAJ |
| description | Abstract Introduction Squamous cell carcinoma (SCC) of the breast is a rare variant of invasive breast cancer that has been classified as metaplastic carcinoma. When a tumor is composed of spindle cells, diagnosis is challenging. Case report A 42-year-old woman with a large mass in the right breast underwent modified radical mastectomy. A pathological examination revealed a tumor with central necrosis in it. The tumor had a sarcomatoid growth pattern and the cells were spindle-shaped with severe atypicality. Immunohistochemical staining showed that P63, P53, vimentin, and CKpan were positive, whereas estrogen receptor and C-erbB-2 were negative. Ki-67 proliferation index was as high as 90%. Therefore, a diagnosis of SCC of the right breast was made. The patient received eight cycles of postoperative chemotherapy with paclitaxel and carboplatin, followed by seven cycles of radiotherapy. During follow-up, the patient also had a left thyroid tumor, and postoperative pathology suggested microinvasive follicular carcinoma. Since breast surgery, the patient has remained disease-free for more than four years. Conclusion SCC of the breast with spindle cell and sarcomatoid features is rare. The diagnosis of such tumors requires exclusion of tumors with similar histological morphologies. |
| first_indexed | 2024-04-24T12:38:16Z |
| format | Article |
| id | doaj.art-520b37f7ada9417e8456a042bf2e41af |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-24T12:38:16Z |
| publishDate | 2024-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-520b37f7ada9417e8456a042bf2e41af2024-04-07T11:22:35ZengSpringerDiscover Oncology2730-60112024-04-011511710.1007/s12672-024-00958-6Primary squamous cell carcinoma of the breast: a case reportXibo Liu0Jiahui Chen1Chuanling Hou2Department of Pathology, Shaoxing People’s HospitalDepartment of Pathology, Shaoxing People’s HospitalDepartment of Pathology, Shaoxing People’s HospitalAbstract Introduction Squamous cell carcinoma (SCC) of the breast is a rare variant of invasive breast cancer that has been classified as metaplastic carcinoma. When a tumor is composed of spindle cells, diagnosis is challenging. Case report A 42-year-old woman with a large mass in the right breast underwent modified radical mastectomy. A pathological examination revealed a tumor with central necrosis in it. The tumor had a sarcomatoid growth pattern and the cells were spindle-shaped with severe atypicality. Immunohistochemical staining showed that P63, P53, vimentin, and CKpan were positive, whereas estrogen receptor and C-erbB-2 were negative. Ki-67 proliferation index was as high as 90%. Therefore, a diagnosis of SCC of the right breast was made. The patient received eight cycles of postoperative chemotherapy with paclitaxel and carboplatin, followed by seven cycles of radiotherapy. During follow-up, the patient also had a left thyroid tumor, and postoperative pathology suggested microinvasive follicular carcinoma. Since breast surgery, the patient has remained disease-free for more than four years. Conclusion SCC of the breast with spindle cell and sarcomatoid features is rare. The diagnosis of such tumors requires exclusion of tumors with similar histological morphologies.https://doi.org/10.1007/s12672-024-00958-6Squamous cell carcinomaSpindle cellBreastPathologyCase report |
| spellingShingle | Xibo Liu Jiahui Chen Chuanling Hou Primary squamous cell carcinoma of the breast: a case report Discover Oncology Squamous cell carcinoma Spindle cell Breast Pathology Case report |
| title | Primary squamous cell carcinoma of the breast: a case report |
| title_full | Primary squamous cell carcinoma of the breast: a case report |
| title_fullStr | Primary squamous cell carcinoma of the breast: a case report |
| title_full_unstemmed | Primary squamous cell carcinoma of the breast: a case report |
| title_short | Primary squamous cell carcinoma of the breast: a case report |
| title_sort | primary squamous cell carcinoma of the breast a case report |
| topic | Squamous cell carcinoma Spindle cell Breast Pathology Case report |
| url | https://doi.org/10.1007/s12672-024-00958-6 |
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