Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus
Systemic lupus erythematosus is characterized by autoantibodies and immune complex deposition. Several autoantibodies against mainly nuclear autoantigens have been described. One of these nuclear autoantigens is the Smith antigen. In this review, we focus on the position of autoantibodies against th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Journal of Translational Autoimmunity |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589909022000168 |
| _version_ | 1811199606694871040 |
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| author | Joyce J.B.C. van Beers Marco W.J. Schreurs |
| author_facet | Joyce J.B.C. van Beers Marco W.J. Schreurs |
| author_sort | Joyce J.B.C. van Beers |
| collection | DOAJ |
| description | Systemic lupus erythematosus is characterized by autoantibodies and immune complex deposition. Several autoantibodies against mainly nuclear autoantigens have been described. One of these nuclear autoantigens is the Smith antigen. In this review, we focus on the position of autoantibodies against the Smith antigen in the classification criteria, the characteristics of the antigen, the production of anti-Smith antibodies in SLE and we discuss the different test methods available, together with their pitfalls, to detect these autoantibodies. |
| first_indexed | 2024-04-12T01:51:33Z |
| format | Article |
| id | doaj.art-520b99807fdf4c93933c630bee639da9 |
| institution | Directory Open Access Journal |
| issn | 2589-9090 |
| language | English |
| last_indexed | 2024-04-12T01:51:33Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Translational Autoimmunity |
| spelling | doaj.art-520b99807fdf4c93933c630bee639da92022-12-22T03:52:56ZengElsevierJournal of Translational Autoimmunity2589-90902022-01-015100155Anti-Sm antibodies in the classification criteria of systemic lupus erythematosusJoyce J.B.C. van Beers0Marco W.J. Schreurs1Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands; Corresponding author. Central Diagnostic Laboratory, Maastricht University Medical Center, Postbus 5800, 6202 AZ, Maastricht, the Netherlands.Laboratory of Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, the NetherlandsSystemic lupus erythematosus is characterized by autoantibodies and immune complex deposition. Several autoantibodies against mainly nuclear autoantigens have been described. One of these nuclear autoantigens is the Smith antigen. In this review, we focus on the position of autoantibodies against the Smith antigen in the classification criteria, the characteristics of the antigen, the production of anti-Smith antibodies in SLE and we discuss the different test methods available, together with their pitfalls, to detect these autoantibodies.http://www.sciencedirect.com/science/article/pii/S2589909022000168Systemic lupus erythematosusClassification criteriaSmith antigen |
| spellingShingle | Joyce J.B.C. van Beers Marco W.J. Schreurs Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus Journal of Translational Autoimmunity Systemic lupus erythematosus Classification criteria Smith antigen |
| title | Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus |
| title_full | Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus |
| title_fullStr | Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus |
| title_full_unstemmed | Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus |
| title_short | Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus |
| title_sort | anti sm antibodies in the classification criteria of systemic lupus erythematosus |
| topic | Systemic lupus erythematosus Classification criteria Smith antigen |
| url | http://www.sciencedirect.com/science/article/pii/S2589909022000168 |
| work_keys_str_mv | AT joycejbcvanbeers antismantibodiesintheclassificationcriteriaofsystemiclupuserythematosus AT marcowjschreurs antismantibodiesintheclassificationcriteriaofsystemiclupuserythematosus |