METTL3 enhances dentinogenesis differentiation of dental pulp stem cells via increasing GDF6 and STC1 mRNA stability

METTL3 enhances dentinogenesis differentiation of dental pulp stem cells via increasing GDF6 and STC1 mRNA stability

Abstract Background The dentinogenesis differentiation of dental pulp stem cells (DPSCs) is controlled by the spatio-temporal expression of differentiation related genes. RNA N6-methyladenosine (m6A) methylation, one of the most abundant internal epigenetic modification in mRNA, influences various e...

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Bibliographic Details
Main Authors: Yue Pan, Ying Liu, Dixin Cui, Sihan Yu, Yachuan Zhou, Xin Zhou, Wei Du, Liwei Zheng, Mian Wan
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Oral Health
Subjects:
Mesenchymal stem cells
Dentinogenesis
Epigenesis
METTL3
RNA stability
Online Access:https://doi.org/10.1186/s12903-023-02836-z

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