Pathogenic mechanism of second hand smoke induced inflammation and COPD
Second hand smoke (SHS) introduces thousands of toxic chemicals into the lung, including carcinogens and oxidants, which cause direct airway epithelium tissue destruction. It can also illicit indirect damage through its effect on signaling pathways related to tissue cell repair and by the abnormal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-08-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00348/full |
| _version_ | 1819293485816086528 |
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| author | Rahel eBirru Y. Peter eDi |
| author_facet | Rahel eBirru Y. Peter eDi |
| author_sort | Rahel eBirru |
| collection | DOAJ |
| description | Second hand smoke (SHS) introduces thousands of toxic chemicals into the lung, including carcinogens and oxidants, which cause direct airway epithelium tissue destruction. It can also illicit indirect damage through its effect on signaling pathways related to tissue cell repair and by the abnormal induction of inflammation into the lung. After repeated exposure to second hand smoke, these symptoms can lead to the development of pulmonary inflammatory disorders, including chronic obstructive pulmonary disease (COPD). COPD is a severe pulmonary disease characterized by chronic inflammation and irreversible tissue destruction. There is no causal cure, as the mechanism behind the development and progression of the disease is still unknown. Recent discoveries implicate genetic predisposition associated with inflammatory response contributed to the development of COPD, linked to irregular innate and adaptive immunity, as well as a risk factor for cancer. The use of animal models for both cigarette smoke (CS) and SHS associated in vivo experiments has been crucial in elucidating the pathogenic mechanisms and genetic components involved in inflammation related development of COPD. |
| first_indexed | 2024-12-24T04:11:11Z |
| format | Article |
| id | doaj.art-520fcbd04a1b4282aad5b5545fd353d7 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-24T04:11:11Z |
| publishDate | 2012-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-520fcbd04a1b4282aad5b5545fd353d72022-12-21T17:16:03ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2012-08-01310.3389/fphys.2012.0034831504Pathogenic mechanism of second hand smoke induced inflammation and COPDRahel eBirru0Y. Peter eDi1University of PittsburghUniversity of PittsburghSecond hand smoke (SHS) introduces thousands of toxic chemicals into the lung, including carcinogens and oxidants, which cause direct airway epithelium tissue destruction. It can also illicit indirect damage through its effect on signaling pathways related to tissue cell repair and by the abnormal induction of inflammation into the lung. After repeated exposure to second hand smoke, these symptoms can lead to the development of pulmonary inflammatory disorders, including chronic obstructive pulmonary disease (COPD). COPD is a severe pulmonary disease characterized by chronic inflammation and irreversible tissue destruction. There is no causal cure, as the mechanism behind the development and progression of the disease is still unknown. Recent discoveries implicate genetic predisposition associated with inflammatory response contributed to the development of COPD, linked to irregular innate and adaptive immunity, as well as a risk factor for cancer. The use of animal models for both cigarette smoke (CS) and SHS associated in vivo experiments has been crucial in elucidating the pathogenic mechanisms and genetic components involved in inflammation related development of COPD.http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00348/fullImmunityInflammationCancerCOPDsecond hand smoke |
| spellingShingle | Rahel eBirru Y. Peter eDi Pathogenic mechanism of second hand smoke induced inflammation and COPD Frontiers in Physiology Immunity Inflammation Cancer COPD second hand smoke |
| title | Pathogenic mechanism of second hand smoke induced inflammation and COPD |
| title_full | Pathogenic mechanism of second hand smoke induced inflammation and COPD |
| title_fullStr | Pathogenic mechanism of second hand smoke induced inflammation and COPD |
| title_full_unstemmed | Pathogenic mechanism of second hand smoke induced inflammation and COPD |
| title_short | Pathogenic mechanism of second hand smoke induced inflammation and COPD |
| title_sort | pathogenic mechanism of second hand smoke induced inflammation and copd |
| topic | Immunity Inflammation Cancer COPD second hand smoke |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00348/full |
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