Correlation of anti-cardiolipin antibodies with right ventricular systolic strain in systemic lupus erythematosus patients
Introduction: The association between anticardiolipin antibodies (aCL) and cardiac disease in the presence of systemic lupus erythematosus (SLE) has been reported in various clinical trials. However, the correlation between these auto-antibodies and right ventricular (RV) function has been inadequat...
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| Format: | Article |
| Language: | English |
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Springer
2017-04-01
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| Series: | Egyptian Journal of Critical Care Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090730317300014 |
| _version_ | 1797280713173630976 |
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| author | Hatem Abdel Rahman Helmy Nady Mohamed Ahmed Abdelrazik Soheir Mustafa Kasem Amal M. Abdel-aal Madleen Adel A. Abdou Ahmed K. Ibrahim |
| author_facet | Hatem Abdel Rahman Helmy Nady Mohamed Ahmed Abdelrazik Soheir Mustafa Kasem Amal M. Abdel-aal Madleen Adel A. Abdou Ahmed K. Ibrahim |
| author_sort | Hatem Abdel Rahman Helmy |
| collection | DOAJ |
| description | Introduction: The association between anticardiolipin antibodies (aCL) and cardiac disease in the presence of systemic lupus erythematosus (SLE) has been reported in various clinical trials. However, the correlation between these auto-antibodies and right ventricular (RV) function has been inadequately investigated.
Objective: The present study investigated the possible correlation of the plasma anticardiolipin antibodies, as a marker of autoimmune phenomenon, with RV functions, assessed by right ventricular speckle tracking, in patients with systemic lupus erythematosus independent of significant pulmonary hypertension, systolic dysfunction or valvular disease.
Methods: Forty-six SLE patients and 20 healthy controls were enrolled in our study and submitted thorough history, complete clinical examination then clinical scoring according to SLEDAI-2K score and then laboratory investigations particularly plasma anticardiolipin Ig_G or Ig_M antibodies. Then echocardiography was done to assess cardiac dimensions, left ventricular systolic functions, right ventricular functions and lastly speckle tracking for assessment of the right ventricular systolic strain.
Results: Most of the study patients were young adult females with long-standing SLE (mean = 26 ± 3.1). All study patients had a high clinical SLE score (>6). All patients were normotensives and non-diabetics. No significant correlation was found between anticardiolipin titre and left ventricular dimensions or systolic functions. Significant negative correlation was found between RV strain and plasma level of both anticardiolipin Ig_M and Ig_G.
Conclusion: The present study identified that with the use of 2D speckle tracking in patients with SLE, right ventricular systolic function was significantly diminished with rising plasma titre of autoimmune (Ig_G or Ig_M) antibodies independent of cardiovascular risk factors. |
| first_indexed | 2024-03-07T16:45:30Z |
| format | Article |
| id | doaj.art-5210eb52429c48cf872092d2ddc8471a |
| institution | Directory Open Access Journal |
| issn | 2090-7303 |
| language | English |
| last_indexed | 2024-03-07T16:45:30Z |
| publishDate | 2017-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Egyptian Journal of Critical Care Medicine |
| spelling | doaj.art-5210eb52429c48cf872092d2ddc8471a2024-03-03T06:32:51ZengSpringerEgyptian Journal of Critical Care Medicine2090-73032017-04-0151172210.1016/j.ejccm.2017.01.001Correlation of anti-cardiolipin antibodies with right ventricular systolic strain in systemic lupus erythematosus patientsHatem Abdel Rahman Helmy0Nady Mohamed Ahmed Abdelrazik1Soheir Mustafa Kasem2Amal M. Abdel-aal3Madleen Adel A. Abdou4Ahmed K. Ibrahim5Faculty of Medicine, Assiut University, Assiut, EgyptFaculty of Medicine, Assiut University, Assiut, EgyptFaculty of Medicine, Assiut University, Assiut, EgyptFaculty of Medicine, Assiut University, Assiut, EgyptFaculty of Medicine, Assiut University, Assiut, EgyptPublic Health & Community Medicine Department, Faculty of Medicine, Assiut University, Assiut, EgyptIntroduction: The association between anticardiolipin antibodies (aCL) and cardiac disease in the presence of systemic lupus erythematosus (SLE) has been reported in various clinical trials. However, the correlation between these auto-antibodies and right ventricular (RV) function has been inadequately investigated. Objective: The present study investigated the possible correlation of the plasma anticardiolipin antibodies, as a marker of autoimmune phenomenon, with RV functions, assessed by right ventricular speckle tracking, in patients with systemic lupus erythematosus independent of significant pulmonary hypertension, systolic dysfunction or valvular disease. Methods: Forty-six SLE patients and 20 healthy controls were enrolled in our study and submitted thorough history, complete clinical examination then clinical scoring according to SLEDAI-2K score and then laboratory investigations particularly plasma anticardiolipin Ig_G or Ig_M antibodies. Then echocardiography was done to assess cardiac dimensions, left ventricular systolic functions, right ventricular functions and lastly speckle tracking for assessment of the right ventricular systolic strain. Results: Most of the study patients were young adult females with long-standing SLE (mean = 26 ± 3.1). All study patients had a high clinical SLE score (>6). All patients were normotensives and non-diabetics. No significant correlation was found between anticardiolipin titre and left ventricular dimensions or systolic functions. Significant negative correlation was found between RV strain and plasma level of both anticardiolipin Ig_M and Ig_G. Conclusion: The present study identified that with the use of 2D speckle tracking in patients with SLE, right ventricular systolic function was significantly diminished with rising plasma titre of autoimmune (Ig_G or Ig_M) antibodies independent of cardiovascular risk factors.http://www.sciencedirect.com/science/article/pii/S2090730317300014Anti-cardiolipin antibodiesRight ventricular strainSystemic lupus erythematosus |
| spellingShingle | Hatem Abdel Rahman Helmy Nady Mohamed Ahmed Abdelrazik Soheir Mustafa Kasem Amal M. Abdel-aal Madleen Adel A. Abdou Ahmed K. Ibrahim Correlation of anti-cardiolipin antibodies with right ventricular systolic strain in systemic lupus erythematosus patients Egyptian Journal of Critical Care Medicine Anti-cardiolipin antibodies Right ventricular strain Systemic lupus erythematosus |
| title | Correlation of anti-cardiolipin antibodies with right ventricular systolic strain in systemic lupus erythematosus patients |
| title_full | Correlation of anti-cardiolipin antibodies with right ventricular systolic strain in systemic lupus erythematosus patients |
| title_fullStr | Correlation of anti-cardiolipin antibodies with right ventricular systolic strain in systemic lupus erythematosus patients |
| title_full_unstemmed | Correlation of anti-cardiolipin antibodies with right ventricular systolic strain in systemic lupus erythematosus patients |
| title_short | Correlation of anti-cardiolipin antibodies with right ventricular systolic strain in systemic lupus erythematosus patients |
| title_sort | correlation of anti cardiolipin antibodies with right ventricular systolic strain in systemic lupus erythematosus patients |
| topic | Anti-cardiolipin antibodies Right ventricular strain Systemic lupus erythematosus |
| url | http://www.sciencedirect.com/science/article/pii/S2090730317300014 |
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