Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19
BackgroundVitamin D deficiency is a substantial public health problem. The present study evaluated the association between vitamin D concentration and hospitalization and mortality risk in patients with coronavirus disease 19 (COVID-19).MethodsThis study used the COronavirus in LOwer Silesia (COLOS)...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231813/full |
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| author | Klaudia Konikowska Katarzyna Kiliś-Pstrusińska Agnieszka Matera-Witkiewicz Krzysztof Kujawa Barbara Adamik Adrian Doroszko Krzysztof Kaliszewski Michał Pomorski Marcin Protasiewicz Janusz Sokołowski Katarzyna Madziarska Ewa Anita Jankowska Ewa Anita Jankowska |
| author_facet | Klaudia Konikowska Katarzyna Kiliś-Pstrusińska Agnieszka Matera-Witkiewicz Krzysztof Kujawa Barbara Adamik Adrian Doroszko Krzysztof Kaliszewski Michał Pomorski Marcin Protasiewicz Janusz Sokołowski Katarzyna Madziarska Ewa Anita Jankowska Ewa Anita Jankowska |
| author_sort | Klaudia Konikowska |
| collection | DOAJ |
| description | BackgroundVitamin D deficiency is a substantial public health problem. The present study evaluated the association between vitamin D concentration and hospitalization and mortality risk in patients with coronavirus disease 19 (COVID-19).MethodsThis study used the COronavirus in LOwer Silesia (COLOS) dataset collected between February 2020 and June 2021. The medical records of 474 patients with confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) infection, and whose vitamin D concentration was measured, were analyzed.ResultsWe determined a significant difference in vitamin D concentration between discharged patients and those who died during hospitalization (p = 0.0096). We also found an effect of vitamin D concentration on the risk of death in patients hospitalized due to COVID-19. As vitamin D concentration increased, the odds ratio (OR) for death slightly decreased (OR = 0.978; 95% confidence interval [CI] = 0.540-0.669). The vitamin D concentration cutoff point was 15.40 ng/ml. In addition, patients with COVID-19 and serum 25-hydroxyvitamin D (25(OH)D) concentrations < 30 ng/ml had a lower survival rate than those with serum 25(OH)D ≥ 30 ng/ml (log-rank test p = 0.0018). Moreover, a Cox regression model showed that patients with an estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m2 and higher vitamin D concentrations had a 2.8% reduced risk of mortality (hazard ratio HR = 0.972; CI = 0.95-0,99; p = 0.0097).ConclusionsThe results indicate an association between 25(OH)D levels in patients with COVID-19 and the final course of hospitalization and risk of death. |
| first_indexed | 2024-03-12T11:22:53Z |
| format | Article |
| id | doaj.art-5211183ecdcd436f8a6ba78c348df2fb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T11:22:53Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5211183ecdcd436f8a6ba78c348df2fb2023-09-01T15:36:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-09-011410.3389/fimmu.2023.12318131231813Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19Klaudia Konikowska0Katarzyna Kiliś-Pstrusińska1Agnieszka Matera-Witkiewicz2Krzysztof Kujawa3Barbara Adamik4Adrian Doroszko5Krzysztof Kaliszewski6Michał Pomorski7Marcin Protasiewicz8Janusz Sokołowski9Katarzyna Madziarska10Ewa Anita Jankowska11Ewa Anita Jankowska12Department of Dietetics and Bromatology, Wroclaw Medical University, Wroclaw, PolandClinical Department of Paediatric Nephrology, Wroclaw Medical University, Wroclaw, PolandScreening of Biological Activity Assays and Collection of Biological Material Laboratory, Wroclaw Medical University Biobank, Wroclaw Medical University, Wroclaw, PolandStatistical Analysis Centre, Wroclaw Medical University, Wroclaw, PolandClinical Department of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, PolandClinical Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Wroclaw, PolandClinical Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, Wroclaw, PolandClinical Department of Gynecology and Obstetrics, Wroclaw Medical University, Wroclaw, PolandInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland0Clinical Department of Emergency Medicine, Wroclaw Medical University, Wroclaw, Poland1Clinical Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, PolandInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland2Institute of Heart Diseases, University Hospital, Wroclaw, PolandBackgroundVitamin D deficiency is a substantial public health problem. The present study evaluated the association between vitamin D concentration and hospitalization and mortality risk in patients with coronavirus disease 19 (COVID-19).MethodsThis study used the COronavirus in LOwer Silesia (COLOS) dataset collected between February 2020 and June 2021. The medical records of 474 patients with confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) infection, and whose vitamin D concentration was measured, were analyzed.ResultsWe determined a significant difference in vitamin D concentration between discharged patients and those who died during hospitalization (p = 0.0096). We also found an effect of vitamin D concentration on the risk of death in patients hospitalized due to COVID-19. As vitamin D concentration increased, the odds ratio (OR) for death slightly decreased (OR = 0.978; 95% confidence interval [CI] = 0.540-0.669). The vitamin D concentration cutoff point was 15.40 ng/ml. In addition, patients with COVID-19 and serum 25-hydroxyvitamin D (25(OH)D) concentrations < 30 ng/ml had a lower survival rate than those with serum 25(OH)D ≥ 30 ng/ml (log-rank test p = 0.0018). Moreover, a Cox regression model showed that patients with an estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m2 and higher vitamin D concentrations had a 2.8% reduced risk of mortality (hazard ratio HR = 0.972; CI = 0.95-0,99; p = 0.0097).ConclusionsThe results indicate an association between 25(OH)D levels in patients with COVID-19 and the final course of hospitalization and risk of death.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231813/fullSARS-CoV-2vitamin DCOVID-19mortalityvitamin D deficiencypublic health |
| spellingShingle | Klaudia Konikowska Katarzyna Kiliś-Pstrusińska Agnieszka Matera-Witkiewicz Krzysztof Kujawa Barbara Adamik Adrian Doroszko Krzysztof Kaliszewski Michał Pomorski Marcin Protasiewicz Janusz Sokołowski Katarzyna Madziarska Ewa Anita Jankowska Ewa Anita Jankowska Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19 Frontiers in Immunology SARS-CoV-2 vitamin D COVID-19 mortality vitamin D deficiency public health |
| title | Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19 |
| title_full | Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19 |
| title_fullStr | Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19 |
| title_full_unstemmed | Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19 |
| title_short | Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19 |
| title_sort | association of serum vitamin d concentration with the final course of hospitalization in patients with covid 19 |
| topic | SARS-CoV-2 vitamin D COVID-19 mortality vitamin D deficiency public health |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231813/full |
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