Gangliosides as Therapeutic Targets for Neurodegenerative Diseases
Gangliosides, sialic acid-containing glycosphingolipids, are abundant in cell membranes and primarily involved in controlling cell signaling and cell communication. The altered ganglioside pattern has been demonstrated in several neurodegenerative diseases, characterized during early-onset or infanc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2024-01-01
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| Series: | Journal of Lipids |
| Online Access: | http://dx.doi.org/10.1155/2024/4530255 |
| _version_ | 1797206036543700992 |
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| author | Orhan Kerim Inci Hande Basırlı Melike Can Selman Yanbul Volkan Seyrantepe |
| author_facet | Orhan Kerim Inci Hande Basırlı Melike Can Selman Yanbul Volkan Seyrantepe |
| author_sort | Orhan Kerim Inci |
| collection | DOAJ |
| description | Gangliosides, sialic acid-containing glycosphingolipids, are abundant in cell membranes and primarily involved in controlling cell signaling and cell communication. The altered ganglioside pattern has been demonstrated in several neurodegenerative diseases, characterized during early-onset or infancy, emphasizing the significance of gangliosides in the brain. Enzymes required for the biosynthesis of gangliosides are linked to several devastating neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP). In this review, we summarized not only the critical roles of biosynthetic enzymes and their inhibitors in ganglioside metabolism but also the efficacy of treatment strategies of ganglioside to address their significance in those diseases. |
| first_indexed | 2024-04-24T09:00:38Z |
| format | Article |
| id | doaj.art-521329955f6e49de90efdf0d3bec2409 |
| institution | Directory Open Access Journal |
| issn | 2090-3049 |
| language | English |
| last_indexed | 2024-04-24T09:00:38Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Lipids |
| spelling | doaj.art-521329955f6e49de90efdf0d3bec24092024-04-16T00:00:03ZengHindawi LimitedJournal of Lipids2090-30492024-01-01202410.1155/2024/4530255Gangliosides as Therapeutic Targets for Neurodegenerative DiseasesOrhan Kerim Inci0Hande Basırlı1Melike Can2Selman Yanbul3Volkan Seyrantepe4Department of Molecular Biology and GeneticsDepartment of Molecular Biology and GeneticsDepartment of Molecular Biology and GeneticsDepartment of Molecular Biology and GeneticsDepartment of Molecular Biology and GeneticsGangliosides, sialic acid-containing glycosphingolipids, are abundant in cell membranes and primarily involved in controlling cell signaling and cell communication. The altered ganglioside pattern has been demonstrated in several neurodegenerative diseases, characterized during early-onset or infancy, emphasizing the significance of gangliosides in the brain. Enzymes required for the biosynthesis of gangliosides are linked to several devastating neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP). In this review, we summarized not only the critical roles of biosynthetic enzymes and their inhibitors in ganglioside metabolism but also the efficacy of treatment strategies of ganglioside to address their significance in those diseases.http://dx.doi.org/10.1155/2024/4530255 |
| spellingShingle | Orhan Kerim Inci Hande Basırlı Melike Can Selman Yanbul Volkan Seyrantepe Gangliosides as Therapeutic Targets for Neurodegenerative Diseases Journal of Lipids |
| title | Gangliosides as Therapeutic Targets for Neurodegenerative Diseases |
| title_full | Gangliosides as Therapeutic Targets for Neurodegenerative Diseases |
| title_fullStr | Gangliosides as Therapeutic Targets for Neurodegenerative Diseases |
| title_full_unstemmed | Gangliosides as Therapeutic Targets for Neurodegenerative Diseases |
| title_short | Gangliosides as Therapeutic Targets for Neurodegenerative Diseases |
| title_sort | gangliosides as therapeutic targets for neurodegenerative diseases |
| url | http://dx.doi.org/10.1155/2024/4530255 |
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