Identification of thyroid carcinoma related genes with mRMR and shortest path approaches.
Thyroid cancer is a malignant neoplasm originated from thyroid cells. It can be classified into papillary carcinomas (PTCs) and anaplastic carcinomas (ATCs). Although ATCs are in an very aggressive status and cause more death than PTCs, their difference is poorly understood at molecular level. In th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3981740?pdf=render |
| _version_ | 1818067968286785536 |
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| author | Yaping Xu Yue Deng Zhenhua Ji Haibin Liu Yueyang Liu Hu Peng Jian Wu Jingping Fan |
| author_facet | Yaping Xu Yue Deng Zhenhua Ji Haibin Liu Yueyang Liu Hu Peng Jian Wu Jingping Fan |
| author_sort | Yaping Xu |
| collection | DOAJ |
| description | Thyroid cancer is a malignant neoplasm originated from thyroid cells. It can be classified into papillary carcinomas (PTCs) and anaplastic carcinomas (ATCs). Although ATCs are in an very aggressive status and cause more death than PTCs, their difference is poorly understood at molecular level. In this study, we focus on the transcriptome difference among PTCs, ATCs and normal tissue from a published dataset including 45 normal tissues, 49 PTCs and 11 ATCs, by applying a machine learning method, maximum relevance minimum redundancy, and identified 9 genes (BCL2, MRPS31, ID4, RASAL2, DLG2, MY01B, ZBTB5, PRKCQ and PPP6C) and 1 miscRNA (miscellaneous RNA, LOC646736) as important candidates involved in the progression of thyroid cancer. We further identified the protein-protein interaction (PPI) sub network from the shortest paths among the 9 genes in a PPI network constructed based on STRING database. Our results may provide insights to the molecular mechanism of the progression of thyroid cancer. |
| first_indexed | 2024-12-10T15:32:06Z |
| format | Article |
| id | doaj.art-5217b205b10142e4af11aa3325577c5c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T15:32:06Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5217b205b10142e4af11aa3325577c5c2022-12-22T01:43:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9402210.1371/journal.pone.0094022Identification of thyroid carcinoma related genes with mRMR and shortest path approaches.Yaping XuYue DengZhenhua JiHaibin LiuYueyang LiuHu PengJian WuJingping FanThyroid cancer is a malignant neoplasm originated from thyroid cells. It can be classified into papillary carcinomas (PTCs) and anaplastic carcinomas (ATCs). Although ATCs are in an very aggressive status and cause more death than PTCs, their difference is poorly understood at molecular level. In this study, we focus on the transcriptome difference among PTCs, ATCs and normal tissue from a published dataset including 45 normal tissues, 49 PTCs and 11 ATCs, by applying a machine learning method, maximum relevance minimum redundancy, and identified 9 genes (BCL2, MRPS31, ID4, RASAL2, DLG2, MY01B, ZBTB5, PRKCQ and PPP6C) and 1 miscRNA (miscellaneous RNA, LOC646736) as important candidates involved in the progression of thyroid cancer. We further identified the protein-protein interaction (PPI) sub network from the shortest paths among the 9 genes in a PPI network constructed based on STRING database. Our results may provide insights to the molecular mechanism of the progression of thyroid cancer.http://europepmc.org/articles/PMC3981740?pdf=render |
| spellingShingle | Yaping Xu Yue Deng Zhenhua Ji Haibin Liu Yueyang Liu Hu Peng Jian Wu Jingping Fan Identification of thyroid carcinoma related genes with mRMR and shortest path approaches. PLoS ONE |
| title | Identification of thyroid carcinoma related genes with mRMR and shortest path approaches. |
| title_full | Identification of thyroid carcinoma related genes with mRMR and shortest path approaches. |
| title_fullStr | Identification of thyroid carcinoma related genes with mRMR and shortest path approaches. |
| title_full_unstemmed | Identification of thyroid carcinoma related genes with mRMR and shortest path approaches. |
| title_short | Identification of thyroid carcinoma related genes with mRMR and shortest path approaches. |
| title_sort | identification of thyroid carcinoma related genes with mrmr and shortest path approaches |
| url | http://europepmc.org/articles/PMC3981740?pdf=render |
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