Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis

Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis

The liver injury leads to an inflammatory response, which causes the activation of hepatic stellate cells (HSCs) that further secrete ECM proteins and play an important role in liver fibrosis. Moreover, the inflammatory response is a driving force for fibrogenesis, which is triggered by many types o...

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Bibliographic Details
Main Authors: Harsh Vardhan Charan, Durgesh Kumar Dwivedi, Sabbir Khan, Gopabandhu Jena
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-03-01
Series:Genes and Diseases
Subjects:
Hepatic stellate cells
Liver fibrosis
NLRP3 activation
NLRP3 inflammasome
NLRP3 inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304221001707

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