Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts.
Prevention of age-associated reduction in muscle mass and function is required to manage a healthy life. Supplemental (-)-Epicatechin (EC) appears to act as a potential regulator for muscle growth and strength. However, its cellular and molecular mechanisms as a potential muscle growth agent have no...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5383328?pdf=render |
| _version_ | 1818014847484297216 |
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| author | Sang-Jin Lee Young-Eun Leem Ga-Yeon Go Younhee Choi Yoo Jin Song Insol Kim Do Yoon Kim Yong Kee Kim Dong-Wan Seo Jong-Sun Kang Gyu-Un Bae |
| author_facet | Sang-Jin Lee Young-Eun Leem Ga-Yeon Go Younhee Choi Yoo Jin Song Insol Kim Do Yoon Kim Yong Kee Kim Dong-Wan Seo Jong-Sun Kang Gyu-Un Bae |
| author_sort | Sang-Jin Lee |
| collection | DOAJ |
| description | Prevention of age-associated reduction in muscle mass and function is required to manage a healthy life. Supplemental (-)-Epicatechin (EC) appears to act as a potential regulator for muscle growth and strength. However, its cellular and molecular mechanisms as a potential muscle growth agent have not been studied well. In the current study, we investigated a role of EC in differentiation of muscle progenitors to gain the molecular insight into how EC regulates muscle growth. EC enhanced myogenic differentiation in a dose-dependent manner through stimulation of promyogenic signaling pathways, p38MAPK and Akt. EC treatment elevated MyoD activity by enhancing its heterodimerization with E protein. Consistently, EC also positively regulated myogenic conversion and differentiation of fibroblasts. In conclusion, EC has a potential as a therapeutic or nutraceutical remedy to treat degenerative muscle diseases or age-related muscle weakness. |
| first_indexed | 2024-04-14T06:49:25Z |
| format | Article |
| id | doaj.art-521a209ac1ea44a4868b544a5cd560e5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T06:49:25Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-521a209ac1ea44a4868b544a5cd560e52022-12-22T02:07:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017527110.1371/journal.pone.0175271Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts.Sang-Jin LeeYoung-Eun LeemGa-Yeon GoYounhee ChoiYoo Jin SongInsol KimDo Yoon KimYong Kee KimDong-Wan SeoJong-Sun KangGyu-Un BaePrevention of age-associated reduction in muscle mass and function is required to manage a healthy life. Supplemental (-)-Epicatechin (EC) appears to act as a potential regulator for muscle growth and strength. However, its cellular and molecular mechanisms as a potential muscle growth agent have not been studied well. In the current study, we investigated a role of EC in differentiation of muscle progenitors to gain the molecular insight into how EC regulates muscle growth. EC enhanced myogenic differentiation in a dose-dependent manner through stimulation of promyogenic signaling pathways, p38MAPK and Akt. EC treatment elevated MyoD activity by enhancing its heterodimerization with E protein. Consistently, EC also positively regulated myogenic conversion and differentiation of fibroblasts. In conclusion, EC has a potential as a therapeutic or nutraceutical remedy to treat degenerative muscle diseases or age-related muscle weakness.http://europepmc.org/articles/PMC5383328?pdf=render |
| spellingShingle | Sang-Jin Lee Young-Eun Leem Ga-Yeon Go Younhee Choi Yoo Jin Song Insol Kim Do Yoon Kim Yong Kee Kim Dong-Wan Seo Jong-Sun Kang Gyu-Un Bae Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts. PLoS ONE |
| title | Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts. |
| title_full | Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts. |
| title_fullStr | Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts. |
| title_full_unstemmed | Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts. |
| title_short | Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts. |
| title_sort | epicatechin elicits myod dependent myoblast differentiation and myogenic conversion of fibroblasts |
| url | http://europepmc.org/articles/PMC5383328?pdf=render |
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