Skin substitutes as treatment for chronic wounds: current and future directions
Chronic wounds such as diabetic foot ulcers and venous leg ulcers place a significant burden on the healthcare system and in some cases, have 5-year mortality rates comparable to cancer. They negatively impact patients’ quality of life due to pain, odor, decreased mobility, and social isolation. Ski...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1154567/full |
| _version_ | 1797732645069651968 |
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| author | Nicole M. Vecin Nicole M. Vecin Robert S. Kirsner |
| author_facet | Nicole M. Vecin Nicole M. Vecin Robert S. Kirsner |
| author_sort | Nicole M. Vecin |
| collection | DOAJ |
| description | Chronic wounds such as diabetic foot ulcers and venous leg ulcers place a significant burden on the healthcare system and in some cases, have 5-year mortality rates comparable to cancer. They negatively impact patients’ quality of life due to pain, odor, decreased mobility, and social isolation. Skin substitutes are an advanced therapy recommended for wounds that fail to show decrease in size with standard care. The choice of substitute used should be based on evidence, which often differs based on wound etiology. There are more than 75 skin substitutes currently available, and that number is rising. In this review, we discuss current management and future directions of chronic wounds while providing a review of available randomized control trial data for various skin substitutes. |
| first_indexed | 2024-03-12T12:16:36Z |
| format | Article |
| id | doaj.art-521a378dde7f4cf9be3f4882ab02a58f |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-12T12:16:36Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-521a378dde7f4cf9be3f4882ab02a58f2023-08-30T10:18:16ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-08-011010.3389/fmed.2023.11545671154567Skin substitutes as treatment for chronic wounds: current and future directionsNicole M. Vecin0Nicole M. Vecin1Robert S. Kirsner2Departments of Medical Education and Public Health Sciences, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United StatesDr. Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United StatesDr. Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United StatesChronic wounds such as diabetic foot ulcers and venous leg ulcers place a significant burden on the healthcare system and in some cases, have 5-year mortality rates comparable to cancer. They negatively impact patients’ quality of life due to pain, odor, decreased mobility, and social isolation. Skin substitutes are an advanced therapy recommended for wounds that fail to show decrease in size with standard care. The choice of substitute used should be based on evidence, which often differs based on wound etiology. There are more than 75 skin substitutes currently available, and that number is rising. In this review, we discuss current management and future directions of chronic wounds while providing a review of available randomized control trial data for various skin substitutes.https://www.frontiersin.org/articles/10.3389/fmed.2023.1154567/fullskin substitutesskin graftschronic woundsdiabetic foot ulcersvenous leg ulcers |
| spellingShingle | Nicole M. Vecin Nicole M. Vecin Robert S. Kirsner Skin substitutes as treatment for chronic wounds: current and future directions Frontiers in Medicine skin substitutes skin grafts chronic wounds diabetic foot ulcers venous leg ulcers |
| title | Skin substitutes as treatment for chronic wounds: current and future directions |
| title_full | Skin substitutes as treatment for chronic wounds: current and future directions |
| title_fullStr | Skin substitutes as treatment for chronic wounds: current and future directions |
| title_full_unstemmed | Skin substitutes as treatment for chronic wounds: current and future directions |
| title_short | Skin substitutes as treatment for chronic wounds: current and future directions |
| title_sort | skin substitutes as treatment for chronic wounds current and future directions |
| topic | skin substitutes skin grafts chronic wounds diabetic foot ulcers venous leg ulcers |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1154567/full |
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