Dissipation during the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer Limit
The Landauer principle sets a thermodynamic bound of <inline-formula><math display="inline"><semantics><mrow><msub><mi>k</mi><mi>B</mi></msub><mi>T</mi></mrow></semantics></math></inline-formula>...
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| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Entropy |
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| Online Access: | https://www.mdpi.com/1099-4300/25/5/779 |
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| author | Uğur Çetiner Oren Raz Madolyn Britt Sergei Sukharev |
| author_facet | Uğur Çetiner Oren Raz Madolyn Britt Sergei Sukharev |
| author_sort | Uğur Çetiner |
| collection | DOAJ |
| description | The Landauer principle sets a thermodynamic bound of <inline-formula><math display="inline"><semantics><mrow><msub><mi>k</mi><mi>B</mi></msub><mi>T</mi></mrow></semantics></math></inline-formula> ln 2 on the energetic cost of erasing each bit of information. It holds for any memory device, regardless of its physical implementation. It was recently shown that carefully built artificial devices can attain this bound. In contrast, biological computation-like processes, e.g., DNA replication, transcription and translation use an order of magnitude more than their Landauer minimum. Here, we show that reaching the Landauer bound is nevertheless possible with biological devices. This is achieved using a mechanosensitive channel of small conductance (MscS) from <i>E. coli</i> as a memory bit. MscS is a fast-acting osmolyte release valve adjusting turgor pressure inside the cell. Our patch-clamp experiments and data analysis demonstrate that under a slow switching regime, the heat dissipation in the course of tension-driven gating transitions in MscS closely approaches its Landauer limit. We discuss the biological implications of this physical trait. |
| first_indexed | 2024-03-11T03:45:39Z |
| format | Article |
| id | doaj.art-521d4e7f8adc4ec19968fec29f47be9d |
| institution | Directory Open Access Journal |
| issn | 1099-4300 |
| language | English |
| last_indexed | 2024-03-11T03:45:39Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Entropy |
| spelling | doaj.art-521d4e7f8adc4ec19968fec29f47be9d2023-11-18T01:16:17ZengMDPI AGEntropy1099-43002023-05-0125577910.3390/e25050779Dissipation during the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer LimitUğur Çetiner0Oren Raz1Madolyn Britt2Sergei Sukharev3Maryland Biophysics Program, Institute for Physical Science and Technology, Department of Biology, University of Maryland, College Park, MD 20742, USADepartment of Physics of Complex Systems, Faculty of Physics, Weizmann Institute of Science, Rehovot 7610001, IsraelMaryland Biophysics Program, Institute for Physical Science and Technology, Department of Biology, University of Maryland, College Park, MD 20742, USAMaryland Biophysics Program, Institute for Physical Science and Technology, Department of Biology, University of Maryland, College Park, MD 20742, USAThe Landauer principle sets a thermodynamic bound of <inline-formula><math display="inline"><semantics><mrow><msub><mi>k</mi><mi>B</mi></msub><mi>T</mi></mrow></semantics></math></inline-formula> ln 2 on the energetic cost of erasing each bit of information. It holds for any memory device, regardless of its physical implementation. It was recently shown that carefully built artificial devices can attain this bound. In contrast, biological computation-like processes, e.g., DNA replication, transcription and translation use an order of magnitude more than their Landauer minimum. Here, we show that reaching the Landauer bound is nevertheless possible with biological devices. This is achieved using a mechanosensitive channel of small conductance (MscS) from <i>E. coli</i> as a memory bit. MscS is a fast-acting osmolyte release valve adjusting turgor pressure inside the cell. Our patch-clamp experiments and data analysis demonstrate that under a slow switching regime, the heat dissipation in the course of tension-driven gating transitions in MscS closely approaches its Landauer limit. We discuss the biological implications of this physical trait.https://www.mdpi.com/1099-4300/25/5/779Landauer’s principleheat dissipationMscS |
| spellingShingle | Uğur Çetiner Oren Raz Madolyn Britt Sergei Sukharev Dissipation during the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer Limit Entropy Landauer’s principle heat dissipation MscS |
| title | Dissipation during the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer Limit |
| title_full | Dissipation during the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer Limit |
| title_fullStr | Dissipation during the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer Limit |
| title_full_unstemmed | Dissipation during the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer Limit |
| title_short | Dissipation during the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer Limit |
| title_sort | dissipation during the gating cycle of the bacterial mechanosensitive ion channel approaches the landauer limit |
| topic | Landauer’s principle heat dissipation MscS |
| url | https://www.mdpi.com/1099-4300/25/5/779 |
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