Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism
Acanthopanax senticosus extract (ASE), a dietary supplement with antifatigue, neuroprotective, and immunomodulatory properties, has been widely used due to its high polyphenol content. Our previous study showed that ASE could be used to treat Parkinson’s disease (PD) as it contains multiple monoamin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1121789/full |
| _version_ | 1811164240145285120 |
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| author | Jingbin Li Yang He Jia Fu Yimin Wang Xing Fan Tian Zhong Hui Zhou |
| author_facet | Jingbin Li Yang He Jia Fu Yimin Wang Xing Fan Tian Zhong Hui Zhou |
| author_sort | Jingbin Li |
| collection | DOAJ |
| description | Acanthopanax senticosus extract (ASE), a dietary supplement with antifatigue, neuroprotective, and immunomodulatory properties, has been widely used due to its high polyphenol content. Our previous study showed that ASE could be used to treat Parkinson’s disease (PD) as it contains multiple monoamine oxidase B inhibitors prescribed in early PD. However, its mechanism remains ambiguous. In this study, we investigated the protective effects of ASE on MPTP-induced PD in mice and explored the underlying mechanisms of action. We found that the administration of ASE significantly improved motor coordination in mice with MPTP-induced PD. As shown by quantitative proteomic analysis, 128 proteins’ expression significantly changed in response to ASE administration, most of which were involved with Fcγ receptor-mediated phagocytosis in macrophages and monocytes signaling pathway, PI3K/AKT signaling pathway, and insulin receptor signaling pathway. Furthermore, the network analysis results showed that ASE modulates protein networks involved in regulating cellular assembly, lipid metabolism, and morphogenesis, all of which have implications for treating PD. Overall, ASE served as a potential therapeutic because it regulated multiple targets to improve motor deficits, which could lay the strong foundation for developing anti-PD dietary supplements. |
| first_indexed | 2024-04-10T15:18:14Z |
| format | Article |
| id | doaj.art-521d6ad0f6c8429ca985067170170404 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T15:18:14Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-521d6ad0f6c8429ca9850671701704042023-02-14T17:44:11ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-02-01910.3389/fnut.2023.11217891121789Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanismJingbin Li0Yang He1Jia Fu2Yimin Wang3Xing Fan4Tian Zhong5Hui Zhou6Key Laboratory of Biotechnology and Bioresources Utilization, Ministry of Education, Institute of Plant Resources, Dalian Minzu University, Dalian, ChinaSchool of Life Sciences, Jilin University, Changchun, ChinaSchool of Health, Zhuhai College of Science and Technology, Zhuhai, ChinaSchool of Life Sciences, Jilin University, Changchun, ChinaSchool of Medicine, Heilongjiang University of Chinese Medicine, Harbin, ChinaFaculty of Medicine, Macau University of Science and Technology, Macao, Macao SAR, ChinaKey Laboratory of Biotechnology and Bioresources Utilization, Ministry of Education, Institute of Plant Resources, Dalian Minzu University, Dalian, ChinaAcanthopanax senticosus extract (ASE), a dietary supplement with antifatigue, neuroprotective, and immunomodulatory properties, has been widely used due to its high polyphenol content. Our previous study showed that ASE could be used to treat Parkinson’s disease (PD) as it contains multiple monoamine oxidase B inhibitors prescribed in early PD. However, its mechanism remains ambiguous. In this study, we investigated the protective effects of ASE on MPTP-induced PD in mice and explored the underlying mechanisms of action. We found that the administration of ASE significantly improved motor coordination in mice with MPTP-induced PD. As shown by quantitative proteomic analysis, 128 proteins’ expression significantly changed in response to ASE administration, most of which were involved with Fcγ receptor-mediated phagocytosis in macrophages and monocytes signaling pathway, PI3K/AKT signaling pathway, and insulin receptor signaling pathway. Furthermore, the network analysis results showed that ASE modulates protein networks involved in regulating cellular assembly, lipid metabolism, and morphogenesis, all of which have implications for treating PD. Overall, ASE served as a potential therapeutic because it regulated multiple targets to improve motor deficits, which could lay the strong foundation for developing anti-PD dietary supplements.https://www.frontiersin.org/articles/10.3389/fnut.2023.1121789/fullAcanthopanax senticosus extractMPTPParkinson’s diseaseproteomicssignaling pathwaytherapeutic mechanism |
| spellingShingle | Jingbin Li Yang He Jia Fu Yimin Wang Xing Fan Tian Zhong Hui Zhou Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism Frontiers in Nutrition Acanthopanax senticosus extract MPTP Parkinson’s disease proteomics signaling pathway therapeutic mechanism |
| title | Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism |
| title_full | Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism |
| title_fullStr | Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism |
| title_full_unstemmed | Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism |
| title_short | Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism |
| title_sort | dietary supplementation of acanthopanax senticosus extract alleviates motor deficits in mptp induced parkinson s disease mice and its underlying mechanism |
| topic | Acanthopanax senticosus extract MPTP Parkinson’s disease proteomics signaling pathway therapeutic mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1121789/full |
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