Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s mouse model

Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s mouse model

IntroductionParkinson’s disease (PD), as a common neurodegenerative disease, currently has no effective therapeutic approaches to delay or stop its progression. There is an urgent need to further define its pathogenesis and develop new therapeutic targets. An increasing number of studies have shown...

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Bibliographic Details
Main Authors: Huidan Weng, Wenjing Song, Kangyue Fu, Yunqian Guan, Guoen Cai, En Huang, Xiaochun Chen, Haiqiang Zou, Qinyong Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson’s disease
SIRT4
quantitative proteomic analysis
bioinformatics
biomarkers
FABP4
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1035444/full

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