Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review
Gestational diabetes mellitus (GDM) is a major public health issue of our century due to its increasing prevalence, affecting 5% to 20% of all pregnancies. The pathogenesis of GDM has not been completely elucidated to date. Increasing evidence suggests the association of environmental factors with g...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/5/383 |
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| author | Ionela Mihaela Vladu Diana Clenciu Adina Mitrea Anca Amzolini Simona Elena Micu Anda Elena Crisan Ion Cristian Efrem Maria Fortofoiu Mircea Catalin Fortofoiu Adrian Mita Anca Barau Alhija Adina Dorina Glodeanu Maria Mota |
| author_facet | Ionela Mihaela Vladu Diana Clenciu Adina Mitrea Anca Amzolini Simona Elena Micu Anda Elena Crisan Ion Cristian Efrem Maria Fortofoiu Mircea Catalin Fortofoiu Adrian Mita Anca Barau Alhija Adina Dorina Glodeanu Maria Mota |
| author_sort | Ionela Mihaela Vladu |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is a major public health issue of our century due to its increasing prevalence, affecting 5% to 20% of all pregnancies. The pathogenesis of GDM has not been completely elucidated to date. Increasing evidence suggests the association of environmental factors with genetic and epigenetic factors in the development of GDM. So far, several metabolomics studies have investigated metabolic disruptions associated with GDM. The aim of this review is to highlight the usefulness of maternal metabolites as diagnosis markers of GDM as well as the importance of both maternal and fetal metabolites as prognosis biomarkers for GDM and GDM’s transition to type 2 diabetes mellitus T2DM. |
| first_indexed | 2024-03-10T03:26:55Z |
| format | Article |
| id | doaj.art-521e571e031047d29b69a726b30f53e9 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T03:26:55Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-521e571e031047d29b69a726b30f53e92023-11-23T12:06:36ZengMDPI AGMetabolites2218-19892022-04-0112538310.3390/metabo12050383Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative ReviewIonela Mihaela Vladu0Diana Clenciu1Adina Mitrea2Anca Amzolini3Simona Elena Micu4Anda Elena Crisan5Ion Cristian Efrem6Maria Fortofoiu7Mircea Catalin Fortofoiu8Adrian Mita9Anca Barau Alhija10Adina Dorina Glodeanu11Maria Mota12Department of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine, Medical Semiology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine, Medical Semiology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Oncology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine and Medical Semiology, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Emergency Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine, Medical Semiology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine, Medical Semiology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine, Medical Semiology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine and Medical Semiology, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaGestational diabetes mellitus (GDM) is a major public health issue of our century due to its increasing prevalence, affecting 5% to 20% of all pregnancies. The pathogenesis of GDM has not been completely elucidated to date. Increasing evidence suggests the association of environmental factors with genetic and epigenetic factors in the development of GDM. So far, several metabolomics studies have investigated metabolic disruptions associated with GDM. The aim of this review is to highlight the usefulness of maternal metabolites as diagnosis markers of GDM as well as the importance of both maternal and fetal metabolites as prognosis biomarkers for GDM and GDM’s transition to type 2 diabetes mellitus T2DM.https://www.mdpi.com/2218-1989/12/5/383gestational diabetes mellitusmetabolomicsobesitycardiovascular riskbiomarkersmetabolic pathways |
| spellingShingle | Ionela Mihaela Vladu Diana Clenciu Adina Mitrea Anca Amzolini Simona Elena Micu Anda Elena Crisan Ion Cristian Efrem Maria Fortofoiu Mircea Catalin Fortofoiu Adrian Mita Anca Barau Alhija Adina Dorina Glodeanu Maria Mota Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review Metabolites gestational diabetes mellitus metabolomics obesity cardiovascular risk biomarkers metabolic pathways |
| title | Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title_full | Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title_fullStr | Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title_full_unstemmed | Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title_short | Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title_sort | maternal and fetal metabolites in gestational diabetes mellitus a narrative review |
| topic | gestational diabetes mellitus metabolomics obesity cardiovascular risk biomarkers metabolic pathways |
| url | https://www.mdpi.com/2218-1989/12/5/383 |
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