Effect of Surgical Periodontal Therapy on Serum C-reactive Protein Levels Using ELISA in Both Chronic and Aggressive Periodontitis Patient
Background: Periodontitis can be defined as a local inflammatory process which mediates destruction of periodontal tissues & is triggered by bacterial insult. In periodontal infections, the levels of C reactive proteins are elevated as compared to the levels in a periodontally healthy individ...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6558/14680_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background: Periodontitis can be defined as a local inflammatory process which mediates destruction of periodontal tissues
& is triggered by bacterial insult. In periodontal infections, the
levels of C reactive proteins are elevated as compared to the
levels in a periodontally healthy individual. The study was done
to determine the relative levels of serum CRP in aggressive,
chronic and periodontally healthy subjects and to evaluate
the effect of surgical periodontal therapy on serum C-reactive
protein levels.
Materials and Methods: Serum samples were collected from
150 participants (50 healthy control patients (non-periodontitis),
50 patients with chronic periodontitis and aggressive periodontitis.
Serum C- reactive protein levels were assessed by means of
immunoturbidimetric assay at baseline for subjects in all the 3
groups and 3 months after completion of surgical therapy.
Results: The mean baseline C-reactive protein (CRP)
concentrations in the Groups I, II and III were 1.65±0.57 mg/L,
3.03±2.14 mg/L and 3.09±2.27 mg/L respectively. After
treatment, the mean C-reactive protein (CRP) levels in Groups II
and III reduced from 3.03±1.67 mg/L to 1.46±1.67 mg/L and from
3.09±1.21 to 1.43±1.21 mg/L respectively. Similar results were
found for probing depth and all indexes in Group II and III after
treatment. Also, the mean attachment loss in Groups II and III
reduced, so the results were highly significant.
Conclusion: Successful periodontal treatment results in significant decrease in serum C-reactive protein (CRP) levels in otherwise healthy subjects. |
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| ISSN: | 2249-782X 0973-709X |