Epidemiological data of national Kawasaki disease registry in Iran, 2007–2019
IntroductionKawasaki disease(KD) is a vasculitis of childhood that tends to influence the coronary arteries. There is no national data about the prevalence of KD in Iran. This study aimed to perform a national registry in Iran for 13 years.MethodsIn this retrospective study, the data for KD extracte...
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Frontiers Media S.A.
2023-01-01
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| author | Leila Shahbaznejad Ali Hosseininasab Leila Mahboobi Hamid Mohammadi Hassan Esmaeili Seyed Majid Farrokhi Far Mohammad Reza Alipour Iraj Sedighi Roxana Mansour Ghanaei Behnam Sobouti Alireza Taremiha Abdol Reza Malek Keyghobad Ghadiri Gholamreza Soleimani Hamed Tabasizadeh Abdolkarim Ghadimi Moghadam Manouchehr Barak Forood Salehi Abarghouei Houman Hashemian Hossein Daryani Nezhad Hamid Reza Sherkatolabbasieh Masoumeh Abedini-Varamini Mohammad Bagher Rahmati Faezeh Sadat Movahedi Mohammad Sadegh Rezai |
| author_facet | Leila Shahbaznejad Ali Hosseininasab Leila Mahboobi Hamid Mohammadi Hassan Esmaeili Seyed Majid Farrokhi Far Mohammad Reza Alipour Iraj Sedighi Roxana Mansour Ghanaei Behnam Sobouti Alireza Taremiha Abdol Reza Malek Keyghobad Ghadiri Gholamreza Soleimani Hamed Tabasizadeh Abdolkarim Ghadimi Moghadam Manouchehr Barak Forood Salehi Abarghouei Houman Hashemian Hossein Daryani Nezhad Hamid Reza Sherkatolabbasieh Masoumeh Abedini-Varamini Mohammad Bagher Rahmati Faezeh Sadat Movahedi Mohammad Sadegh Rezai |
| author_sort | Leila Shahbaznejad |
| collection | DOAJ |
| description | IntroductionKawasaki disease(KD) is a vasculitis of childhood that tends to influence the coronary arteries. There is no national data about the prevalence of KD in Iran. This study aimed to perform a national registry in Iran for 13 years.MethodsIn this retrospective study, the data for KD extracted from medical records of <19 year-old patients admitted to tertiary hospitals in Iran between 2007 and 2019 were recorded in the national KD registry system. Age, admission date, gender, location, and presence of KD criteria, laboratory and echocardiography findings, and treatment modalities were evaluated. Complete KD was considered if ≥4 clinical criteria of the KD existed and otherwise, incomplete KD was considered.ResultsData from 1,682 KD patients including 999(59.39%) boys and 683(40.61%) girls and male/female ratio of 1.46 were evaluated. The mean age was 3.08 ± 2.49 years and 1465(87%) were living in urban regions. The yearly incidence of the disease was between 2.62 to 3.03 from 2015 to 2019. The highest age-specific incidence was observed in children <1-year-old. Incomplete and resistant KD included 1,321(78.54%) and 9(0.54%) patients, respectively. Abnormal echocardiography was detected in 619(36.80%) patients. Leukocytosis, with dominancy of neutrophils, anemia, thrombocytosis and increased ESR and CRP were the most noticeable laboratory findings. No death due to KD disease was reported.ConclusionBased on this study, most of the KD cases are presented with atypical presentation in Iran. So, increasing awareness of primary healthcare workers by educating and updating their data is very important in timely diagnosis and management of the disease. |
| first_indexed | 2024-04-10T23:36:06Z |
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| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T23:36:06Z |
| publishDate | 2023-01-01 |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-521ff65bf11b49bb95b1fa7143d0fbf82023-01-11T17:11:37ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-01-011010.3389/fped.2022.988371988371Epidemiological data of national Kawasaki disease registry in Iran, 2007–2019Leila Shahbaznejad0Ali Hosseininasab1Leila Mahboobi2Hamid Mohammadi3Hassan Esmaeili4Seyed Majid Farrokhi Far5Mohammad Reza Alipour6Iraj Sedighi7Roxana Mansour Ghanaei8Behnam Sobouti9Alireza Taremiha10Abdol Reza Malek11Keyghobad Ghadiri12Gholamreza Soleimani13Hamed Tabasizadeh14Abdolkarim Ghadimi Moghadam15Manouchehr Barak16Forood Salehi Abarghouei17Houman Hashemian18Hossein Daryani Nezhad19Hamid Reza Sherkatolabbasieh20Masoumeh Abedini-Varamini21Mohammad Bagher Rahmati22Faezeh Sadat Movahedi23Mohammad Sadegh Rezai24Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, IranResearch Center of Tropical and Infectious Diseases, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, IranDepartment of Pediatrics, School of Medicine, Ardabil University of Medical Sciences, Ardabil, IranNeonatal Research Center, Namazi Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, IranIschemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, IranSchool of Medicine, Heshmatie Hospital, Sabzevar University of Medical Sciences, Sabzevar, IranCardiovascular Research Center, Afshar Heart Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Pediatrics, School of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, IranPediatric Infections Research Center, Research Institute for Children Health, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran0Department of Pediatrics, School of Medicine, Shahid Motahari Burns Hospital, Iran University of Medical Sciences, Tehran, Iran1Department of Pediatrics, School of Medicine, Qods Teaching Hospital, Qazvin University of Medical Sciences, Qazvin, Iran2Department of Pediatrics, School of Medicine, Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran3Infectious Diseases Research Center, Research Institute for Health, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran4Children and Adolescents Health Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran5Department of Clinical Sciences, School of Medicine, Imam Hossein Hospital, Bahar Hospital, Shahroud University of Medical Sciences, Shahroud, Iran6Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, IranDepartment of Pediatrics, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran7Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran8Department of Pediatrics, School of Medicine, 17 Shahrivar Hospital, Guilan University of Medical Sciences, Rasht, Iran9School of Medicine, Islamic Azad University of Tonekabon, Tonekabon, Iran0Department of Pediatrics, School of Medicine Shahid Rahimi Hospital, Shahid Madani Hospital, Lorestan University of Medical Sciences, Lorestan, Iran1Department of Pediatrics, School of Medicine, Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran2Department of Pediatric Infectious Diseases, Children's Clinical Research Development Center, Hormozgan University of Medical Sciences, Bandar abbas, IranPediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, IranPediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, IranIntroductionKawasaki disease(KD) is a vasculitis of childhood that tends to influence the coronary arteries. There is no national data about the prevalence of KD in Iran. This study aimed to perform a national registry in Iran for 13 years.MethodsIn this retrospective study, the data for KD extracted from medical records of <19 year-old patients admitted to tertiary hospitals in Iran between 2007 and 2019 were recorded in the national KD registry system. Age, admission date, gender, location, and presence of KD criteria, laboratory and echocardiography findings, and treatment modalities were evaluated. Complete KD was considered if ≥4 clinical criteria of the KD existed and otherwise, incomplete KD was considered.ResultsData from 1,682 KD patients including 999(59.39%) boys and 683(40.61%) girls and male/female ratio of 1.46 were evaluated. The mean age was 3.08 ± 2.49 years and 1465(87%) were living in urban regions. The yearly incidence of the disease was between 2.62 to 3.03 from 2015 to 2019. The highest age-specific incidence was observed in children <1-year-old. Incomplete and resistant KD included 1,321(78.54%) and 9(0.54%) patients, respectively. Abnormal echocardiography was detected in 619(36.80%) patients. Leukocytosis, with dominancy of neutrophils, anemia, thrombocytosis and increased ESR and CRP were the most noticeable laboratory findings. No death due to KD disease was reported.ConclusionBased on this study, most of the KD cases are presented with atypical presentation in Iran. So, increasing awareness of primary healthcare workers by educating and updating their data is very important in timely diagnosis and management of the disease.https://www.frontiersin.org/articles/10.3389/fped.2022.988371/fullkawasaki diseaseregistrynationalIranstrawberry tongue |
| spellingShingle | Leila Shahbaznejad Ali Hosseininasab Leila Mahboobi Hamid Mohammadi Hassan Esmaeili Seyed Majid Farrokhi Far Mohammad Reza Alipour Iraj Sedighi Roxana Mansour Ghanaei Behnam Sobouti Alireza Taremiha Abdol Reza Malek Keyghobad Ghadiri Gholamreza Soleimani Hamed Tabasizadeh Abdolkarim Ghadimi Moghadam Manouchehr Barak Forood Salehi Abarghouei Houman Hashemian Hossein Daryani Nezhad Hamid Reza Sherkatolabbasieh Masoumeh Abedini-Varamini Mohammad Bagher Rahmati Faezeh Sadat Movahedi Mohammad Sadegh Rezai Epidemiological data of national Kawasaki disease registry in Iran, 2007–2019 Frontiers in Pediatrics kawasaki disease registry national Iran strawberry tongue |
| title | Epidemiological data of national Kawasaki disease registry in Iran, 2007–2019 |
| title_full | Epidemiological data of national Kawasaki disease registry in Iran, 2007–2019 |
| title_fullStr | Epidemiological data of national Kawasaki disease registry in Iran, 2007–2019 |
| title_full_unstemmed | Epidemiological data of national Kawasaki disease registry in Iran, 2007–2019 |
| title_short | Epidemiological data of national Kawasaki disease registry in Iran, 2007–2019 |
| title_sort | epidemiological data of national kawasaki disease registry in iran 2007 2019 |
| topic | kawasaki disease registry national Iran strawberry tongue |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.988371/full |
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