Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system

Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system

Abstract Background Traumatic knee injuries in humans trigger an immediate increase in synovial fluid levels of inflammatory cytokines that accompany impact damage to joint tissues. We developed a human in vitro cartilage-bone-synovium (CBS) coculture model to study the role of mechanical injury and...

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Bibliographic Details
Main Authors: Garima Dwivedi, Lisa Flaman, Begum Alaybeyoglu, André Struglics, Eliot H. Frank, Susan Chubinskya, Stephen B. Trippel, Vicki Rosen, Murat Cirit, Alan J. Grodzinsky
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Arthritis Research & Therapy
Subjects:
Post-traumatic osteoarthritis
Inflammatory cytokines
Osteochondral-synovium coculture
Cartilage mechanical injury
Cartilage-bone-synovium metabolomics
Glycosaminoglycan
Online Access:https://doi.org/10.1186/s13075-022-02881-z

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