Essential Oil of <i>Bursera morelensis</i> Promotes Cell Migration on Fibroblasts: In Vitro Assays
Essential oils (EOs) are complex mixtures of volatile natural compounds. We have extensively studied the EO of <i>Bursera morelensis</i>, which demonstrates antibacterial, antifungal, anti-inflammatory, and wound-healing activities. The objective of this work was to determine the effect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/17/6258 |
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| author | Judith Salas-Oropeza Marco Aurelio Rodriguez-Monroy Manuel Jimenez-Estrada Armando Perez-Torres Andres Eliu Castell-Rodriguez Rodolfo Becerril-Millan Katia Jarquin-Yanez Maria Margarita Canales-Martinez |
| author_facet | Judith Salas-Oropeza Marco Aurelio Rodriguez-Monroy Manuel Jimenez-Estrada Armando Perez-Torres Andres Eliu Castell-Rodriguez Rodolfo Becerril-Millan Katia Jarquin-Yanez Maria Margarita Canales-Martinez |
| author_sort | Judith Salas-Oropeza |
| collection | DOAJ |
| description | Essential oils (EOs) are complex mixtures of volatile natural compounds. We have extensively studied the EO of <i>Bursera morelensis</i>, which demonstrates antibacterial, antifungal, anti-inflammatory, and wound-healing activities. The objective of this work was to determine the effect of this EO on fibroblast migration in a three-dimensional in vitro model. For the three-dimensional in vitro model, a series of fibrin hydrogel scaffolds (FSs) were built in which fibroblasts were cultured and subsequently stimulated with fibroblast growth factor (FGF) or EO. The results demonstrated that these FSs are appropriate for fibroblast culture, since no decrease in cell viability or changes in cell proliferation were found. The results also showed that this EO promotes cell migration four hours after stimulation, and the formation of cell projections (filopodia) outside the SF was observed. From these results, we confirmed that part of the mechanism of action of the essential oil of <i>B. morelensis</i> during the healing process is the stimulation of fibroblast migration to the wound site. |
| first_indexed | 2024-03-10T23:17:18Z |
| format | Article |
| id | doaj.art-52258ecaf1ba49199e01385107988081 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T23:17:18Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-52258ecaf1ba49199e013851079880812023-11-19T08:33:29ZengMDPI AGMolecules1420-30492023-08-012817625810.3390/molecules28176258Essential Oil of <i>Bursera morelensis</i> Promotes Cell Migration on Fibroblasts: In Vitro AssaysJudith Salas-Oropeza0Marco Aurelio Rodriguez-Monroy1Manuel Jimenez-Estrada2Armando Perez-Torres3Andres Eliu Castell-Rodriguez4Rodolfo Becerril-Millan5Katia Jarquin-Yanez6Maria Margarita Canales-Martinez7Laboratorio de Farmacognosia, UBIPRO Facultad de Estudios Superiores Iztacala, UNAM, Tlalnepantla C.P. 54090, MexicoLaboratorio de Investigación Biomédica en Productos Naturales, Carrera de Medicina Facultad de Estudios Superiores-Iztacala, UNAM, Tlalnepantla C.P. 54090, MexicoInstituto de Química-UNAM, Circuito Exterior, Ciudad Universitaria, Ciudad de México D.F. 04510, MexicoFacultad de Medicina-UNAM, Circuito Exterior, Ciudad Universitaria, Ciudad de México D.F. 04510, MexicoFacultad de Medicina-UNAM, Circuito Exterior, Ciudad Universitaria, Ciudad de México D.F. 04510, MexicoLaboratorio de Farmacognosia, UBIPRO Facultad de Estudios Superiores Iztacala, UNAM, Tlalnepantla C.P. 54090, MexicoFacultad de Medicina-UNAM, Circuito Exterior, Ciudad Universitaria, Ciudad de México D.F. 04510, MexicoLaboratorio de Farmacognosia, UBIPRO Facultad de Estudios Superiores Iztacala, UNAM, Tlalnepantla C.P. 54090, MexicoEssential oils (EOs) are complex mixtures of volatile natural compounds. We have extensively studied the EO of <i>Bursera morelensis</i>, which demonstrates antibacterial, antifungal, anti-inflammatory, and wound-healing activities. The objective of this work was to determine the effect of this EO on fibroblast migration in a three-dimensional in vitro model. For the three-dimensional in vitro model, a series of fibrin hydrogel scaffolds (FSs) were built in which fibroblasts were cultured and subsequently stimulated with fibroblast growth factor (FGF) or EO. The results demonstrated that these FSs are appropriate for fibroblast culture, since no decrease in cell viability or changes in cell proliferation were found. The results also showed that this EO promotes cell migration four hours after stimulation, and the formation of cell projections (filopodia) outside the SF was observed. From these results, we confirmed that part of the mechanism of action of the essential oil of <i>B. morelensis</i> during the healing process is the stimulation of fibroblast migration to the wound site.https://www.mdpi.com/1420-3049/28/17/6258<i>Bursera</i>essential oilcell migrationwound healing |
| spellingShingle | Judith Salas-Oropeza Marco Aurelio Rodriguez-Monroy Manuel Jimenez-Estrada Armando Perez-Torres Andres Eliu Castell-Rodriguez Rodolfo Becerril-Millan Katia Jarquin-Yanez Maria Margarita Canales-Martinez Essential Oil of <i>Bursera morelensis</i> Promotes Cell Migration on Fibroblasts: In Vitro Assays Molecules <i>Bursera</i> essential oil cell migration wound healing |
| title | Essential Oil of <i>Bursera morelensis</i> Promotes Cell Migration on Fibroblasts: In Vitro Assays |
| title_full | Essential Oil of <i>Bursera morelensis</i> Promotes Cell Migration on Fibroblasts: In Vitro Assays |
| title_fullStr | Essential Oil of <i>Bursera morelensis</i> Promotes Cell Migration on Fibroblasts: In Vitro Assays |
| title_full_unstemmed | Essential Oil of <i>Bursera morelensis</i> Promotes Cell Migration on Fibroblasts: In Vitro Assays |
| title_short | Essential Oil of <i>Bursera morelensis</i> Promotes Cell Migration on Fibroblasts: In Vitro Assays |
| title_sort | essential oil of i bursera morelensis i promotes cell migration on fibroblasts in vitro assays |
| topic | <i>Bursera</i> essential oil cell migration wound healing |
| url | https://www.mdpi.com/1420-3049/28/17/6258 |
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