Inhibition of Wdr5 Attenuates Ang-II-Induced Fibroblast-to-Myofibroblast Transition in Cardiac Fibrosis by Regulating Mdm2/P53/P21 Pathway

Inhibition of Wdr5 Attenuates Ang-II-Induced Fibroblast-to-Myofibroblast Transition in Cardiac Fibrosis by Regulating Mdm2/P53/P21 Pathway

Cardiac fibrosis is an important pathological process in many diseases. Wdr5 catalyzes the trimethylation of lysine K4 on histone H3. The effects of Wdr5 on the cardiac fibrosis phenotype and the activation or transformation of cardiac fibroblasts were investigated by Ang-II-infused mice by osmotic...

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Bibliographic Details
Main Authors: Jiali Yuan, Hong Peng, Binfeng Mo, Chengye Yin, Guojian Fang, Yingze Li, Yuepeng Wang, Renhua Chen, Qunshan Wang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
cardiac fibrosis
Wdr5
H3K4me3
epigenetics
cell senescence
Online Access:https://www.mdpi.com/2218-273X/12/11/1574

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