Effect of Adding Human Chorionic Gonadotropin to The Endometrial Preparation Protocol in Frozen Embryo Transfer Cycles
Background: Human chorionic gonadotropin (HCG), one of the initial embryonic signals, is probably a major regulator of the embryo-endometrial relationship. This study aims to assess the advantage of HCG supplementation during the secretory phase of hormonally prepared cycles for the transfer of cryo...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2012-10-01
|
| Series: | International Journal of Fertility and Sterility |
| Subjects: | |
| Online Access: | http://www.ijfs.ir/article_45141_26538c44f3f19cbd5ec0231db157c6d9.pdf |
| _version_ | 1811294858931863552 |
|---|---|
| author | Maryam Eftekhar Elham Rahmani Tahereh Eftekhar |
| author_facet | Maryam Eftekhar Elham Rahmani Tahereh Eftekhar |
| author_sort | Maryam Eftekhar |
| collection | DOAJ |
| description | Background: Human chorionic gonadotropin (HCG), one of the initial embryonic signals, is probably a major regulator of the embryo-endometrial relationship. This study aims to assess the advantage of HCG supplementation during the secretory phase of hormonally prepared cycles for the transfer of cryopreserved-thawed embryos. Materials and Methods: This study was a randomized clinical trial. Infertile women who were candidates for frozen-thawed embryo transfers entered the study and were divided into two groups, HCG and control. The endometrial preparation method was similar in both groups: all women received estradiol valerate (6 mg) po per day from the second day of the menstrual cycle and progesterone in oil (100 mg) intramuscular (I.M.) when the endometrial thickness reached 8 mm. Estradiol and progesterone were continued until the tenth week of gestation. In the HCG group, patients received an HCG 5000 IU injection on the first day of progesterone administration and the day of embryo transfer. Results: In this study, 130 couples participated: 65 in the HCG group and 65 in the control group. There was no statistically significant difference between groups regarding basic characteristics. Implantation rate, chemical pregnancy, clinical pregnancy, ongoing pregnancy, and abortion rates were similar in both groups. Conclusion: Although HCG has some advantages in assisted reproductive technology (ART) cycles, our study did not show any benefit of HCG supplementation during the secretory phase of frozen cycles (Registration Number: IRCT201107266420N4). |
| first_indexed | 2024-04-13T05:23:52Z |
| format | Article |
| id | doaj.art-5226f4335ede497e9205df20297dd572 |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-04-13T05:23:52Z |
| publishDate | 2012-10-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-5226f4335ede497e9205df20297dd5722022-12-22T03:00:39ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782012-10-016317517845141Effect of Adding Human Chorionic Gonadotropin to The Endometrial Preparation Protocol in Frozen Embryo Transfer CyclesMaryam Eftekhar0Elham Rahmani1Tahereh Eftekhar2Department of Obstetrics and Gynecology, Yazd Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Obstetrics and Gynecology, Bushehr University of Medical Sciences, Bushehr, IranDepartment of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, IranBackground: Human chorionic gonadotropin (HCG), one of the initial embryonic signals, is probably a major regulator of the embryo-endometrial relationship. This study aims to assess the advantage of HCG supplementation during the secretory phase of hormonally prepared cycles for the transfer of cryopreserved-thawed embryos. Materials and Methods: This study was a randomized clinical trial. Infertile women who were candidates for frozen-thawed embryo transfers entered the study and were divided into two groups, HCG and control. The endometrial preparation method was similar in both groups: all women received estradiol valerate (6 mg) po per day from the second day of the menstrual cycle and progesterone in oil (100 mg) intramuscular (I.M.) when the endometrial thickness reached 8 mm. Estradiol and progesterone were continued until the tenth week of gestation. In the HCG group, patients received an HCG 5000 IU injection on the first day of progesterone administration and the day of embryo transfer. Results: In this study, 130 couples participated: 65 in the HCG group and 65 in the control group. There was no statistically significant difference between groups regarding basic characteristics. Implantation rate, chemical pregnancy, clinical pregnancy, ongoing pregnancy, and abortion rates were similar in both groups. Conclusion: Although HCG has some advantages in assisted reproductive technology (ART) cycles, our study did not show any benefit of HCG supplementation during the secretory phase of frozen cycles (Registration Number: IRCT201107266420N4).http://www.ijfs.ir/article_45141_26538c44f3f19cbd5ec0231db157c6d9.pdfartimplantationfrozen embryohcg |
| spellingShingle | Maryam Eftekhar Elham Rahmani Tahereh Eftekhar Effect of Adding Human Chorionic Gonadotropin to The Endometrial Preparation Protocol in Frozen Embryo Transfer Cycles International Journal of Fertility and Sterility art implantation frozen embryo hcg |
| title | Effect of Adding Human Chorionic Gonadotropin to The Endometrial Preparation Protocol in Frozen Embryo Transfer Cycles |
| title_full | Effect of Adding Human Chorionic Gonadotropin to The Endometrial Preparation Protocol in Frozen Embryo Transfer Cycles |
| title_fullStr | Effect of Adding Human Chorionic Gonadotropin to The Endometrial Preparation Protocol in Frozen Embryo Transfer Cycles |
| title_full_unstemmed | Effect of Adding Human Chorionic Gonadotropin to The Endometrial Preparation Protocol in Frozen Embryo Transfer Cycles |
| title_short | Effect of Adding Human Chorionic Gonadotropin to The Endometrial Preparation Protocol in Frozen Embryo Transfer Cycles |
| title_sort | effect of adding human chorionic gonadotropin to the endometrial preparation protocol in frozen embryo transfer cycles |
| topic | art implantation frozen embryo hcg |
| url | http://www.ijfs.ir/article_45141_26538c44f3f19cbd5ec0231db157c6d9.pdf |
| work_keys_str_mv | AT maryameftekhar effectofaddinghumanchorionicgonadotropintotheendometrialpreparationprotocolinfrozenembryotransfercycles AT elhamrahmani effectofaddinghumanchorionicgonadotropintotheendometrialpreparationprotocolinfrozenembryotransfercycles AT tahereheftekhar effectofaddinghumanchorionicgonadotropintotheendometrialpreparationprotocolinfrozenembryotransfercycles |