Population pharmacokinetics and limited sampling strategy for therapeutic drug monitoring of mycophenolate mofetil in Japanese patients with lupus nephritis

Population pharmacokinetics and limited sampling strategy for therapeutic drug monitoring of mycophenolate mofetil in Japanese patients with lupus nephritis

Abstract Background Mycophenolate mofetil (MMF), a prodrug of the immunosuppressive agent mycophenolic acid (MPA), is difficult to administer because of the pharmacokinetic complexity of MPA. Although dosage adjustment according to the 12-h area under the concentration–time curve (AUC0-12) is though...

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Main Authors: Tomoko Mizaki, Hironobu Nobata, Shogo Banno, Makoto Yamaguchi, Hiroshi Kinashi, Shiho Iwagaitsu, Takuji Ishimoto, Yukiko Kuru, Masafumi Ohnishi, Ken-ichi Sako, Yasuhiko Ito
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Mycophenolate mofetil
Mycophenolic acid
Lupus nephritis
Limited sampling strategy
Population pharmacokinetics
Online Access:https://doi.org/10.1186/s40780-022-00271-w

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