Redox regulation of protein nanomechanics in health and disease: Lessons from titin
The nanomechanics of sarcomeric proteins is a key contributor to the mechanical output of muscle. Among them, titin emerges as a main target for the regulation of the stiffness of striated muscle. In the last years, single-molecule experiments by Atomic Force Microscopy (AFM) have demonstrated that...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-02-01
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| Series: | Redox Biology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221323171830939X |
| _version_ | 1818790324595589120 |
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| author | Elías Herrero-Galán Inés Martínez-Martín Jorge Alegre-Cebollada |
| author_facet | Elías Herrero-Galán Inés Martínez-Martín Jorge Alegre-Cebollada |
| author_sort | Elías Herrero-Galán |
| collection | DOAJ |
| description | The nanomechanics of sarcomeric proteins is a key contributor to the mechanical output of muscle. Among them, titin emerges as a main target for the regulation of the stiffness of striated muscle. In the last years, single-molecule experiments by Atomic Force Microscopy (AFM) have demonstrated that redox posttranslational modifications are strong modulators of the mechanical function of titin. Here, we provide an overview of the recent development of the redox mechanobiology of titin, and suggest avenues of research to better understand how the stiffness of molecules, cells and tissues are modulated by redox signaling in health and disease. |
| first_indexed | 2024-12-18T14:53:39Z |
| format | Article |
| id | doaj.art-5228866ce710473384e680fa7f2e19a9 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-18T14:53:39Z |
| publishDate | 2019-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-5228866ce710473384e680fa7f2e19a92022-12-21T21:04:06ZengElsevierRedox Biology2213-23172019-02-0121Redox regulation of protein nanomechanics in health and disease: Lessons from titinElías Herrero-Galán0Inés Martínez-Martín1Jorge Alegre-Cebollada2Corresponding authors.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, SpainCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, SpainCorresponding authors.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, SpainThe nanomechanics of sarcomeric proteins is a key contributor to the mechanical output of muscle. Among them, titin emerges as a main target for the regulation of the stiffness of striated muscle. In the last years, single-molecule experiments by Atomic Force Microscopy (AFM) have demonstrated that redox posttranslational modifications are strong modulators of the mechanical function of titin. Here, we provide an overview of the recent development of the redox mechanobiology of titin, and suggest avenues of research to better understand how the stiffness of molecules, cells and tissues are modulated by redox signaling in health and disease.http://www.sciencedirect.com/science/article/pii/S221323171830939X |
| spellingShingle | Elías Herrero-Galán Inés Martínez-Martín Jorge Alegre-Cebollada Redox regulation of protein nanomechanics in health and disease: Lessons from titin Redox Biology |
| title | Redox regulation of protein nanomechanics in health and disease: Lessons from titin |
| title_full | Redox regulation of protein nanomechanics in health and disease: Lessons from titin |
| title_fullStr | Redox regulation of protein nanomechanics in health and disease: Lessons from titin |
| title_full_unstemmed | Redox regulation of protein nanomechanics in health and disease: Lessons from titin |
| title_short | Redox regulation of protein nanomechanics in health and disease: Lessons from titin |
| title_sort | redox regulation of protein nanomechanics in health and disease lessons from titin |
| url | http://www.sciencedirect.com/science/article/pii/S221323171830939X |
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