Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1

Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1

Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a mutant variant of Lamin A. Recently, HGPS studies have gained relevance because unraveling its underlying mechanism would help to understand physiological aging. We previously repor...

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Bibliographic Details
Main Authors: Feliciano Monterrubio-Ledezma, Fernando Navarro-García, Lourdes Massieu, Ricardo Mondragón-Flores, Luz Adriana Soto-Ponce, Jonathan J. Magaña, Bulmaro Cisneros
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
Hutchinson-Gilford progeria syndrome
mitochondria
CRM1
leptomycin B
mitophagy
PGC-1α
Online Access:https://www.mdpi.com/2073-4409/12/2/275

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