Time Under 90% Oxygen Saturation and Systemic Hypertension in Patients with Obstructive Sleep Apnea Syndrome
Le Wang, Dong-hui Wei, Jing Zhang, Jie Cao Department of Respiratory and Critical Care, Tianjin Medical University General Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Jing Zhang; Jie Cao, Department of Respiratory and Critical Care, Tianjin Medical University General Hospital, Tianj...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-11-01
|
| Series: | Nature and Science of Sleep |
| Subjects: | |
| Online Access: | https://www.dovepress.com/time-under-90-oxygen-saturation-and-systemic-hypertension-in-patients--peer-reviewed-fulltext-article-NSS |
| _version_ | 1811211901160390656 |
|---|---|
| author | Wang L Wei DH Zhang J Cao J |
| author_facet | Wang L Wei DH Zhang J Cao J |
| author_sort | Wang L |
| collection | DOAJ |
| description | Le Wang, Dong-hui Wei, Jing Zhang, Jie Cao Department of Respiratory and Critical Care, Tianjin Medical University General Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Jing Zhang; Jie Cao, Department of Respiratory and Critical Care, Tianjin Medical University General Hospital, Tianjin, 300052, People’s Republic of China, Tel +86 22-60361612 ; +86 22-60362567, Fax +86 22-60261612, Email tjzyyzhangjing@163.com; tjcaojie@163.comPurpose: The diagnosis and severity of obstructive sleep apnea (OSA) are commonly based on the apnea hypopnea index (AHI). However, patients with similar severity AHIs may show widely varying comorbidities and risks for cardiovascular disease, which may be associated with different severities of nocturnal hypoxia. The percentage of cumulative time with oxygen saturation below 90% in total sleep time (T90) is receiving increasing attention in OSA research because it describes the duration and degree of hypoxia during the whole sleep. This study aimed to explore the distribution of T90 in OSA patients with similar severity and to evaluate the relationship between T90 and hypertension.Patients and Methods: A total of 775 patients with OSA were enrolled in this study, all participants were divided into groups according to the T90 value: light hypoxia (T90≤ 5%), mild hypoxia (T90 accounted for 5– 10%), moderate hypoxia (T90 accounted for 10– 25%), and severe hypoxia (T90> 25%). Multivariate logistic regression analysis was performed to assess the association between T90 and hypertension.Results: Of the patients with mild OSA, 94.33% had light hypoxia, and 88.64% of moderate OSA patients had light hypoxia. The proportions of light, mild, moderate, and severe hypoxia among patients with severe OSA were 28.60%, 17.69%, 21.40%, and 32.31%, respectively. After adjustment for potential confounders, the risk of hypertension in patients with severe OSA increased according to the severity categories of T90. The odds ratio for T90 accounting for 10– 25% relative to T90≤ 5% was 2.544 (95%confidence interval, 1.254– 5.164; P=0.010) and as high as 2.692 (95%confidence interval, 1.403– 5.166; P=0.003) in patients with T90> 25%.Conclusion: OSA patients with similar degree of AHI may have different T90 values, especially in severe OSA. A higher T90 was independently associated with the risk of hypertension after adjustment for traditional risk factors in patients with severe OSA. Our findings highlight the potential role for T90 in predicting hypertension in patients severe OSA.Keywords: apnea hypopnea index, hypertension, obstructive sleep apnea, T90 |
| first_indexed | 2024-04-12T05:21:09Z |
| format | Article |
| id | doaj.art-522ab3b8695446c1a65b3224b2d70c16 |
| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-04-12T05:21:09Z |
| publishDate | 2022-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Nature and Science of Sleep |
| spelling | doaj.art-522ab3b8695446c1a65b3224b2d70c162022-12-22T03:46:28ZengDove Medical PressNature and Science of Sleep1179-16082022-11-01Volume 142123213279993Time Under 90% Oxygen Saturation and Systemic Hypertension in Patients with Obstructive Sleep Apnea SyndromeWang LWei DHZhang JCao JLe Wang, Dong-hui Wei, Jing Zhang, Jie Cao Department of Respiratory and Critical Care, Tianjin Medical University General Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Jing Zhang; Jie Cao, Department of Respiratory and Critical Care, Tianjin Medical University General Hospital, Tianjin, 300052, People’s Republic of China, Tel +86 22-60361612 ; +86 22-60362567, Fax +86 22-60261612, Email tjzyyzhangjing@163.com; tjcaojie@163.comPurpose: The diagnosis and severity of obstructive sleep apnea (OSA) are commonly based on the apnea hypopnea index (AHI). However, patients with similar severity AHIs may show widely varying comorbidities and risks for cardiovascular disease, which may be associated with different severities of nocturnal hypoxia. The percentage of cumulative time with oxygen saturation below 90% in total sleep time (T90) is receiving increasing attention in OSA research because it describes the duration and degree of hypoxia during the whole sleep. This study aimed to explore the distribution of T90 in OSA patients with similar severity and to evaluate the relationship between T90 and hypertension.Patients and Methods: A total of 775 patients with OSA were enrolled in this study, all participants were divided into groups according to the T90 value: light hypoxia (T90≤ 5%), mild hypoxia (T90 accounted for 5– 10%), moderate hypoxia (T90 accounted for 10– 25%), and severe hypoxia (T90> 25%). Multivariate logistic regression analysis was performed to assess the association between T90 and hypertension.Results: Of the patients with mild OSA, 94.33% had light hypoxia, and 88.64% of moderate OSA patients had light hypoxia. The proportions of light, mild, moderate, and severe hypoxia among patients with severe OSA were 28.60%, 17.69%, 21.40%, and 32.31%, respectively. After adjustment for potential confounders, the risk of hypertension in patients with severe OSA increased according to the severity categories of T90. The odds ratio for T90 accounting for 10– 25% relative to T90≤ 5% was 2.544 (95%confidence interval, 1.254– 5.164; P=0.010) and as high as 2.692 (95%confidence interval, 1.403– 5.166; P=0.003) in patients with T90> 25%.Conclusion: OSA patients with similar degree of AHI may have different T90 values, especially in severe OSA. A higher T90 was independently associated with the risk of hypertension after adjustment for traditional risk factors in patients with severe OSA. Our findings highlight the potential role for T90 in predicting hypertension in patients severe OSA.Keywords: apnea hypopnea index, hypertension, obstructive sleep apnea, T90https://www.dovepress.com/time-under-90-oxygen-saturation-and-systemic-hypertension-in-patients--peer-reviewed-fulltext-article-NSSapnea hypopnea indexhypertensionobstructive sleep apneat90 |
| spellingShingle | Wang L Wei DH Zhang J Cao J Time Under 90% Oxygen Saturation and Systemic Hypertension in Patients with Obstructive Sleep Apnea Syndrome Nature and Science of Sleep apnea hypopnea index hypertension obstructive sleep apnea t90 |
| title | Time Under 90% Oxygen Saturation and Systemic Hypertension in Patients with Obstructive Sleep Apnea Syndrome |
| title_full | Time Under 90% Oxygen Saturation and Systemic Hypertension in Patients with Obstructive Sleep Apnea Syndrome |
| title_fullStr | Time Under 90% Oxygen Saturation and Systemic Hypertension in Patients with Obstructive Sleep Apnea Syndrome |
| title_full_unstemmed | Time Under 90% Oxygen Saturation and Systemic Hypertension in Patients with Obstructive Sleep Apnea Syndrome |
| title_short | Time Under 90% Oxygen Saturation and Systemic Hypertension in Patients with Obstructive Sleep Apnea Syndrome |
| title_sort | time under 90 oxygen saturation and systemic hypertension in patients with obstructive sleep apnea syndrome |
| topic | apnea hypopnea index hypertension obstructive sleep apnea t90 |
| url | https://www.dovepress.com/time-under-90-oxygen-saturation-and-systemic-hypertension-in-patients--peer-reviewed-fulltext-article-NSS |
| work_keys_str_mv | AT wangl timeunder90oxygensaturationandsystemichypertensioninpatientswithobstructivesleepapneasyndrome AT weidh timeunder90oxygensaturationandsystemichypertensioninpatientswithobstructivesleepapneasyndrome AT zhangj timeunder90oxygensaturationandsystemichypertensioninpatientswithobstructivesleepapneasyndrome AT caoj timeunder90oxygensaturationandsystemichypertensioninpatientswithobstructivesleepapneasyndrome |