Metabolomic Alterations in the Tear Fluids of Patients With Superior Limbic Keratoconjunctivitis

Metabolomic Alterations in the Tear Fluids of Patients With Superior Limbic Keratoconjunctivitis

PurposeSuperior limbic keratoconjunctivitis (SLK) is a bilateral, chronic inflammatory disease that recurs for up to several years; however, the fundamental processes involved in its pathogenic mechanisms remain unknown. We aimed to investigate the metabolomic alterations in the tear fluids of patie...

Full description

Bibliographic Details
Main Authors:	Yan Zong, Chao Cheng, Kunke Li, Ran Xue, Ziyan Chen, Xiuping Liu, Kaili Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Series:	Frontiers in Medicine
Subjects:	metabolomics tear fluids superior limbic keratoconjunctivitis liquid chromatography with tandem mass spectrometry (LC-MS/MS) metabolites
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2021.797630/full

Similar Items

Combination of Bandage Contact Lens and Autologous Serum Eye Drop for the Treatment of Superior Limbic Keratoconjunctivitis
by: Noor NA
Published: (2023-04-01)

Metabolism of Zearalenone in the Course of Beer Fermentation
by: Naoki Mochizuki, et al.
Published: (2011-02-01)

Metabolic profiling of liver and faeces in mice infected with echinococcosis
by: Mingxing Zhu, et al.
Published: (2021-06-01)

Metabolomics of the Bio-Degradation Process of Aflatoxin B1 by Actinomycetes at an Initial pH of 6.0
by: Manal Eshelli, et al.
Published: (2015-02-01)

Tear ferning in normal dogs and dogs with keratoconjunctivitis sicca
by: David Williams, et al.
Published: (2017-09-01)

Targeted Metabolomics: The LC-MS/MS Based Quantification of the Metabolites Involved in the Methylation Biochemical Pathways
by: Georgia Ntasi, et al.
Published: (2021-06-01)

Gas and Liquid Chromatography Mass Spectrometry as a Tool for Elucidating Volatile Organic Compounds (VOCs) and Metabolites in Maternal Milk: A Perspective on Infants’ Health Risk Assessment
by: Evangelia N. Tzanetou, et al.
Published: (2024-02-01)

Vitamin D and Its Metabolites Status before and during Chemotherapy in Caucasian Breast Cancer Patients
by: Małgorzata Kimsa-Furdzik, et al.
Published: (2023-09-01)

Development and validation of a reliable LC–MS/MS method for quantitative analysis of usnic acid in Cladonia uncialis
by: Natalia Sveshnikova, et al.
Published: (2019-08-01)

Development and validation of a novel LC-MS/MS assay for C-peptide in human serum
by: Benjamin Y. Owusu, et al.
Published: (2021-01-01)

Changes in tear protein profile in dogs with keratoconjunctivitis sicca following topical treatment using cyclosporine A
by: Metita Sussadee, et al.
Published: (2021-06-01)

Proteomic Insights into the Biology of the Most Important Foodborne Parasites in Europe
by: Robert Stryiński, et al.
Published: (2020-10-01)

Multiplexed quantification of insulin and C-peptide by LC-MS/MS without the use of antibodies
by: North Foulon, et al.
Published: (2022-08-01)

A Proteomics Signature of Mild Hypospadias: A Pilot Study
by: Coriness Piñeyro-Ruiz, et al.
Published: (2020-12-01)

An Extensive Study of Phenol Red Thread as a Novel Non-Invasive Tear Sampling Technique for Proteomics Studies: Comparison with Two Commonly Used Methods
by: Gábor Kecskeméti, et al.
Published: (2022-08-01)

Qualitative and quantitative mass spectrometry comparison of characteristic galactosyl lactose isomers from goat milk at different lactation stages
by: Xinyi Wang, et al.
Published: (2022-09-01)

Early Detection of Recurrence and Progress Using Serum Steroid Profiling by LC–MS/MS in Patients with Adrenocortical Carcinoma
by: Otilia Kimpel, et al.
Published: (2023-12-01)

Residue Analysis and Assessment of the Risk of Dietary Exposure to Domoic Acid in Shellfish from the Coastal Areas of China
by: Guanchao Zheng, et al.
Published: (2022-12-01)

Plasma and Urine Pharmacokinetics of Oral Fosfomycin Tromethamine in Dogs
by: Nattha Jariyapamornkoon, et al.
Published: (2023-06-01)

The Metabolomic Approach Reveals the Alteration in Human Serum and Cerebrospinal Fluid Composition in Parkinson’s Disease Patients
by: Szymon Plewa, et al.
Published: (2021-09-01)

Accurate Quantification of β-Lactoglobulin in Bovine Milk by HPLC-IDMS
by: CHEN Yan-qiu;XU Zeng-yi;YU Jing-lan;LI Liang-jun;XU Zhong-jie;LEI Wen
Published: (2023-05-01)

Improving LC-MS/MS measurements of steroids with differential mobility spectrometry
by: Yubo Chai, et al.
Published: (2023-11-01)

In Silico Optimization of Mass Spectrometry Fragmentation Strategies in Metabolomics
by: Joe Wandy, et al.
Published: (2019-10-01)

Effects of Aging, Long-Term and Lifelong Exercise on the Urinary Metabolic Footprint of Rats
by: Anastasia Tzimou, et al.
Published: (2020-11-01)

Systemic Treatment of Immune-Mediated Keratoconjunctivitis Sicca with Allogeneic Stem Cells Improves the Schirmer Tear Test Score in a Canine Spontaneous Model of Disease
by: Manuel Hermida-Prieto, et al.
Published: (2021-12-01)

Research Note: Changes in chicken egg yolk metabolome during its formation
by: Yi Wang, et al.
Published: (2023-12-01)

Urinary markers of Mycobacterium tuberculosis and dysbiosis in paediatric tuberculous meningitis cases undergoing treatment
by: Simon Isaiah, et al.
Published: (2024-03-01)

Contamination Status and Risk Assessment of Paralytic Shellfish Toxins in Shellfish along the Coastal Areas of China
by: Guanchao Zheng, et al.
Published: (2024-01-01)

Detection and Quantification of Acrylamide in Second Trimester Amniotic Fluid Using a Novel LC-MS/MS Technique to Determine Whether High Acrylamide Content during Pregnancy Is Associated with Fetal Growth
by: Nikolaos Vrachnis, et al.
Published: (2023-11-01)

A Proteomic Study for the Discovery of Beef Tenderness Biomarkers and Prediction of Warner–Bratzler Shear Force Measured on <i>Longissimus thoracis</i> Muscles of Young Limousin-Sired Bulls
by: Yao Zhu, et al.
Published: (2021-04-01)

Anti-Influenza Activity of the Ribonuclease Binase: Cellular Targets Detected by Quantitative Proteomics
by: Vera Ulyanova, et al.
Published: (2020-11-01)

Differences in the Levels of the Selected Phytoestrogens and Stable Isotopes in Organic vs. Conventional Hops and Beer
by: Jelena B. Golubović, et al.
Published: (2021-08-01)

Degradation of Aflatoxin B1 during the Fermentation of Alcoholic Beverages
by: Naoki Mochizuki, et al.
Published: (2013-06-01)

Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older Patient
by: Rebecca Parr, et al.
Published: (2020-06-01)

Analysis of the Gluten Map in Beers by LC-MS/MS Combined with Optimized Extraction Protocol
by: YU Xin-he1,2, et al.
Published: (2022-03-01)

Does Cannabis Extract Obtained From Cannabis Flowers With Maximum Allowed Residual Level of Aflatoxins and Ochratoxin a Have an Impact on Human Safety and Health?
by: Tijana Serafimovska, et al.
Published: (2021-11-01)

Efficacy and safety of pranoprofen in the treatment of keratoconjunctivitis sicca
by: Zhen Chen, et al.
Published: (2018-02-01)

Widely Targeted HPLC-MS/MS Metabolomics Analysis Reveals Natural Metabolic Insights in Insects
by: Zhaoxin Li, et al.
Published: (2023-06-01)

Residue Degradation and Risk Assessment of Difenoconazole and Its Metabolite during Tea Growing, Processing and Brewing by Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry Determination
by: Min Wang, et al.
Published: (2024-04-01)

Improved Quantitative Approach for Monitorization of Gangliosides Structural Diversity in Fungal Cell Factories by LC-MS/MS
by: Javier-Fernando Montero-Bullón, et al.
Published: (2022-12-01)