When fat goes down, prostate cancer is on the ropes
Reprogrammed lipid metabolism and persistent androgen receptor signaling commonly mark aggressive prostate cancer. We describe that targeting de-novo lipogenesis deprives prostate cancer cells of substrates and fuel, while inhibiting androgen receptor signaling. Our study uncovers the interplay betw...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1595308 |
| _version_ | 1797677143473258496 |
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| author | Giorgia Zadra Massimo Loda |
| author_facet | Giorgia Zadra Massimo Loda |
| author_sort | Giorgia Zadra |
| collection | DOAJ |
| description | Reprogrammed lipid metabolism and persistent androgen receptor signaling commonly mark aggressive prostate cancer. We describe that targeting de-novo lipogenesis deprives prostate cancer cells of substrates and fuel, while inhibiting androgen receptor signaling. Our study uncovers the interplay between lipogenesis and androgen receptor and proposes novel combinatorial therapeutic approaches. |
| first_indexed | 2024-03-11T22:40:39Z |
| format | Article |
| id | doaj.art-522eda850e414ee6965f4dcd2f334438 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:39Z |
| publishDate | 2019-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-522eda850e414ee6965f4dcd2f3344382023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-05-016310.1080/23723556.2019.15953081595308When fat goes down, prostate cancer is on the ropesGiorgia Zadra0Massimo Loda1Dana-Farber Cancer InstituteDana-Farber Cancer InstituteReprogrammed lipid metabolism and persistent androgen receptor signaling commonly mark aggressive prostate cancer. We describe that targeting de-novo lipogenesis deprives prostate cancer cells of substrates and fuel, while inhibiting androgen receptor signaling. Our study uncovers the interplay between lipogenesis and androgen receptor and proposes novel combinatorial therapeutic approaches.http://dx.doi.org/10.1080/23723556.2019.1595308metastatic prostate cancerfatty acid synthesisandrogen receptorlipid metabolismreticulum endoplasmic stress response |
| spellingShingle | Giorgia Zadra Massimo Loda When fat goes down, prostate cancer is on the ropes Molecular & Cellular Oncology metastatic prostate cancer fatty acid synthesis androgen receptor lipid metabolism reticulum endoplasmic stress response |
| title | When fat goes down, prostate cancer is on the ropes |
| title_full | When fat goes down, prostate cancer is on the ropes |
| title_fullStr | When fat goes down, prostate cancer is on the ropes |
| title_full_unstemmed | When fat goes down, prostate cancer is on the ropes |
| title_short | When fat goes down, prostate cancer is on the ropes |
| title_sort | when fat goes down prostate cancer is on the ropes |
| topic | metastatic prostate cancer fatty acid synthesis androgen receptor lipid metabolism reticulum endoplasmic stress response |
| url | http://dx.doi.org/10.1080/23723556.2019.1595308 |
| work_keys_str_mv | AT giorgiazadra whenfatgoesdownprostatecancerisontheropes AT massimoloda whenfatgoesdownprostatecancerisontheropes |