Targeting long non-coding RNA MALAT1 reverses cancerous phenotypes of breast cancer cells through microRNA-561-3p/TOP2A axis

Abstract Non-coding RNAs, including Inc-RNA and miRNA, have been reported to regulate gene expression and are associated with cancer progression. MicroRNA-561-3p (miR-561-3p), as a tumor suppressor, has been reported to play a role in preventing cancer cell progression, and MALAT1 (Lnc-RNA) have als...

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Bibliographic Details
Main Authors: Sara Hajibabaei, Nahid Nafissi, Yasamin Azimi, Reza Mahdian, Fatemeh Rahimi-Jamnani, Vahideh Valizadeh, Mohammad Hessam Rafiee, Masoumeh Azizi
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35639-x