PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective
Cardiovascular diseases are important causes of mortality and morbidity worldwide. Vascular smooth muscle cells (SMCs) are major components of blood vessels and are involved in physiologic and pathophysiologic conditions. In healthy vessels, vascular SMCs contribute to vasotone and regulate blood fl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/9/1/4 |
| _version_ | 1827664898102919168 |
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| author | Margarida Lorigo Nelson Oliveira Elisa Cairrao |
| author_facet | Margarida Lorigo Nelson Oliveira Elisa Cairrao |
| author_sort | Margarida Lorigo |
| collection | DOAJ |
| description | Cardiovascular diseases are important causes of mortality and morbidity worldwide. Vascular smooth muscle cells (SMCs) are major components of blood vessels and are involved in physiologic and pathophysiologic conditions. In healthy vessels, vascular SMCs contribute to vasotone and regulate blood flow by cyclic nucleotide intracellular pathways. However, vascular SMCs lose their contractile phenotype under pathological conditions and alter contractility or signalling mechanisms, including cyclic nucleotide compartmentation. In the present review, we focus on compartmentalized signaling of cyclic nucleotides in vascular smooth muscle. A deeper understanding of these mechanisms clarifies the most relevant axes for the regulation of vascular tone. Furthermore, this allows the detection of possible changes associated with pathological processes, which may be of help for the discovery of novel drugs. |
| first_indexed | 2024-03-10T01:15:05Z |
| format | Article |
| id | doaj.art-523119da79d94cf388e4f39ba359d645 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T01:15:05Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-523119da79d94cf388e4f39ba359d6452023-11-23T14:10:56ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-12-0191410.3390/jcdd9010004PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical PerspectiveMargarida Lorigo0Nelson Oliveira1Elisa Cairrao2Health Sciences Research Centre (CICS-UBI), University of Beira Interior, 6200-506 Covilha, PortugalUDI-IPG, Research Unit for Inland Development, Department of Social Sciences and Communication, Polytechnic Institute of Guarda, 6300-654 Guarda, PortugalHealth Sciences Research Centre (CICS-UBI), University of Beira Interior, 6200-506 Covilha, PortugalCardiovascular diseases are important causes of mortality and morbidity worldwide. Vascular smooth muscle cells (SMCs) are major components of blood vessels and are involved in physiologic and pathophysiologic conditions. In healthy vessels, vascular SMCs contribute to vasotone and regulate blood flow by cyclic nucleotide intracellular pathways. However, vascular SMCs lose their contractile phenotype under pathological conditions and alter contractility or signalling mechanisms, including cyclic nucleotide compartmentation. In the present review, we focus on compartmentalized signaling of cyclic nucleotides in vascular smooth muscle. A deeper understanding of these mechanisms clarifies the most relevant axes for the regulation of vascular tone. Furthermore, this allows the detection of possible changes associated with pathological processes, which may be of help for the discovery of novel drugs.https://www.mdpi.com/2308-3425/9/1/4compartmentationcAMPcGMPvascular smooth muscle cellscardiovascular diseases |
| spellingShingle | Margarida Lorigo Nelson Oliveira Elisa Cairrao PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective Journal of Cardiovascular Development and Disease compartmentation cAMP cGMP vascular smooth muscle cells cardiovascular diseases |
| title | PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective |
| title_full | PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective |
| title_fullStr | PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective |
| title_full_unstemmed | PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective |
| title_short | PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective |
| title_sort | pde mediated cyclic nucleotide compartmentation in vascular smooth muscle cells from basic to a clinical perspective |
| topic | compartmentation cAMP cGMP vascular smooth muscle cells cardiovascular diseases |
| url | https://www.mdpi.com/2308-3425/9/1/4 |
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