Topical Application of Orabase Bromelain Gel Reduces Inflammatory Process, Bone Loss and Steatosis in Experimental Periodontitis

Topical Application of Orabase Bromelain Gel Reduces Inflammatory Process, Bone Loss and Steatosis in Experimental Periodontitis

Abstract This study aimed to develop a bromelain-based gel and evaluate its effects in a ligature-induced periodontitis model in rats. The bromelain-based gel was formulated in two concentrations (1% and 10%). Ten animals were used per group: Control, Periodontitis, Periodontitis + Neutral Gel, Peri...

Full description

Bibliographic Details
Main Authors:	Even Herlany Pereira Alves, Hélio Mateus Silva Nascimento, Luiz Felipe de Carvalho França, Any Carolina Cardoso Guimarães Vasconcelos, Larissa dos Santos Pessoa, Felipe Rodolfo Pereira da Silva, John Arlley Sousa Pinho de Lira, Paulo Roberto Carneiro Gomes, André dos Santos Carvalho, André Luiz dos Reis Barbosa, Daniel Fernando Pereira Vasconcelos
Format:	Article
Language:	English
Published:	Instituto de Tecnologia do Paraná (Tecpar) 2025-02-01
Series:	Brazilian Archives of Biology and Technology
Subjects:	Periodontal disease Bone biology Periodontal medicine Inflammation
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132025000100300&lng=en&tlng=en

Similar Items

Bromelain: A potential strategy for the adjuvant treatment of periodontitis
by: Felipe Rodolfo Pereira da Silva, et al.
Published: (2016-01-01)

New Insights in Hydrogels for Periodontal Regeneration
by: Mafalda S. Santos, et al.
Published: (2023-11-01)

The effect of bromelain in periodontal surgery: a double-blind randomized placebo-controlled trial
by: Hossein Babazade, et al.
Published: (2023-05-01)

Association between periodontitis and lung disease
by: Fabiano Rito Macedo, et al.
Published: (2010-04-01)

Clinical response to nonsurgical periodontal therapy is associated with decreased serum leukocyte count and uric acid levels in kidney transplant recipients
by: Samira Vasconcelos Gomes, et al.
Published: (2024-09-01)

Evaluation of clinical periodontal conditions in smokers and non-smokers
by: Lucinara Ignez Tavares Luzzi, et al.
Published: (2007-12-01)

Propolis effects in periodontal disease seem to affect coronavirus disease: a meta-analysis
by: Silvia Helena de Carvalho SALES-PERES, et al.
Published: (2023-03-01)

Dental Status of Firefighters of Rio de Janeiro State and Comparison with Brazilian Oral Health Surveys
by: André Luis Caúla, et al.
Published: (2021-11-01)

Recent Advances on Electrospun Nanofibers for Periodontal Regeneration
by: Mafalda S. Santos, et al.
Published: (2023-04-01)

Brazilian Red Propolis Is as Effective as Amoxicillin in Controlling Red-Complex of Multispecies Subgingival Mature Biofilm In Vitro
by: Kadmo Azevedo de Figueiredo, et al.
Published: (2020-07-01)

Non-significant association between − 330 T/G polymorphism in interleukin-2 gene and chronic periodontitis: findings from a meta-analysis
by: Felipe Rodolfo Pereira da Silva, et al.
Published: (2020-02-01)

In Vitro Response of Dental Stem Cells on Decellularized Extracellular Matrix-Derived Hydrogels
by: Alexandra B. dos Santos, et al.
Published: (2022-12-01)

Bromelain inhibits the inflammation and senescence effect in diabetic periodontitis: A preliminary in vitro study
by: Hung-Chieh Lu, et al.
Published: (2023-04-01)

Epidemiological evaluation of apical periodontitis prevalence in an urban Brazilian population
by: Teresa BERLINCK, et al.
Published: (2015-01-01)

Improvement of cervical dentin hypersensitivity after two different treatments
by: Maysa Santana Cavalcante, et al.

Isolamento e identificação da microbiota periodontal de cães da raça Pastor Alemão Isolate and identify of periodontal microbiota of German Shepherd dogs
by: Carla Afonso da Silva Bitencourt Braga, et al.
Published: (2005-04-01)

Exploiting the Power of Decellularized ECM for Periodontal Tissue Regeneration
by: Marta S. Carvalho
Published: (2022-12-01)

Effectiveness of Bromelain in the control of postoperative pain after periodontal surgery: A crossover randomized clinical trial
by: Masoumeh Faramarzi, et al.
Published: (2023-06-01)

Associação entre doença periodontal e síndrome coronariana aguda Association between periodontal disease and acute coronary syndrome
by: Rafael Luiz Rech, et al.
Published: (2007-02-01)

Evaluation of an Electronic Periodontal Probe Versus a Manual Probe
by: Antonio Renatus, et al.
Published: (2016-11-01)

Characterization of bruxing patients with periodontal disease treated at “3 de Octubre” Dental Clinic
by: Yudisel Rivera-Estornell, et al.
Published: (2020-10-01)

Prevalence and Risk Factors of Bone and Dental Lesions in Neotropical Deer
by: Tamires Ataides Silva, et al.
Published: (2024-06-01)

The Nexus Between Periodontal Inflammation and Dysbiosis
by: Thomas E. Van Dyke, et al.
Published: (2020-03-01)

Prevalencia de enfermedad periodontal y factores de riesgo asociados. Policlínico Pedro Borrás, Pinar del Río Prevalence of periodontal disease and associated risk factors. "Pedro Borras" outpatient clinic, Pinar del Rio
by: Leyda Yenima Pérez Hernández, et al.
Published: (2011-06-01)

Enzimas proteolíticas relacionadas con la enfermedad periodontal inflamatoria
by: Bárbara E. García Triana, et al.
Published: (1998-08-01)

Clinical and microbiological evaluation of non-surgical periodontal therapy in obese and non-obese individuals with periodontitis: a 9-month prospective longitudinal study
by: Felipe da Silva PERALTA, et al.

Interaction between periodontal disease and colorectal cancer
by: Thalles Yurgen Balduino, et al.
Published: (2024-12-01)

Influence of ovariectomy combined with lack of masticatory force in the evolution of periodontal disease
by: Noala Vicensoto Moreira Milhan, et al.
Published: (2015-10-01)

Oral Phenotype and Salivary Microbiome of Individuals With Papillon–Lefèvre Syndrome
by: Giulia Melo Lettieri, et al.
Published: (2021-08-01)

Perícia Odontológica em Âmbito Trabalhista – Relato de Caso
by: Cristiane Escudeiro dos Santos
Published: (2015-11-01)

A new classification scheme for periodontal and peri-implant diseases and conditions – Second part: Periodontitis
by: István Gera
Published: (2018-12-01)

Periodontal status of Pakistani orthodontic patients
by: Yousuf MOOSA, et al.
Published: (2015-01-01)

Host response mechanisms in periodontal diseases
by: Nora SILVA, et al.
Published: (2015-06-01)

Clinical cases in periodontics /
by: Karimbux, Nadeem
Published: (2012)

Prevalence of periodontopathogens and Candida spp. in smokers after nonsurgical periodontal therapy – a pilot study
by: Gabriela Alessandra da Cruz Galhardo CAMARGO, et al.

Salivary IgA and periodontal treatment needs in diabetic patients
by: Luciana Salles Branco-de-Almeida, et al.
Published: (2011-12-01)

Biomarkers in biological fluids in adults with periodontitis and/or obesity: A meta-analysis
by: Renata Scheeren Brum, et al.
Published: (2020-01-01)

PERIODONTAL PHENOTYPE: A CLINICAL AND CURRENT VIEW
by: Lucas Mendes Gabri, et al.
Published: (2021-06-01)

Changes in Serum Inflammatory Markers and in Clinical Periodontal Condition After Non-Surgical Periodontal Treatment in Hypertensive Patients
by: Francina María Escobar Arregoces, et al.
Published: (2025-02-01)

Relationship between Carotid Intima-Media Thickness, Periodontal Disease, and Systemic Inflammation Biomarkers in an Adult Population
by: Catalina Latorre Uriza, et al.
Published: (2024-06-01)