Granular Cell Ameloblastoma: A Rare Case Report and Literature Review
Ameloblastomas are rare, benign, aggressive neoplasms of odontogenic epithelial origin. Among the various types of ameloblastomas, granular cell ameloblastoma is rare and accounts for less than 5% of the total. Granular cells are epithelial in origin. The distinct histopathological characteristics o...
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| Format: | Article |
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JCDR Research and Publications Private Limited
2023-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/17500/61118_CE[Ra1]_F(IS)_PF1(AKA_OM)_PN(SHU).pdf |
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| author | Samiha Jameel Ahmed Khan Madhuri Gawande Alka Hande Swati Patil Archana Sonone |
| author_facet | Samiha Jameel Ahmed Khan Madhuri Gawande Alka Hande Swati Patil Archana Sonone |
| author_sort | Samiha Jameel Ahmed Khan |
| collection | DOAJ |
| description | Ameloblastomas are rare, benign, aggressive neoplasms of odontogenic epithelial origin. Among the various types of ameloblastomas, granular cell ameloblastoma is rare and accounts for less than 5% of the total. Granular cells are epithelial in origin. The distinct histopathological characteristics of granular cells are associated with high lysosomal content in tumour cells cytoplasm. A 43-year-old female patient presented with a painful swelling on the left-side of the jaw. The diagnosis was based on clinical, radiological and histopathological examination. A complete surgical resection was done. Histopathology showed features of granular cell ameloblastoma. The operative procedure was uneventful. Granular cell ameloblastoma has a high tendency for recurrence. Around 33.3% recurrence is reported, according to various studies. This rate is much higher than other subtypes of ameloblastoma, which are more common. Hence, it is essential to provide appropriate surgical treatment on time to prevent tumour recurrence and metastasis.This case report aims to highlight the unique features of granular cell ameloblastoma, distinguishing it from other subtypes and discussing the pathogenesis and treatment modalities. |
| first_indexed | 2024-04-10T00:27:37Z |
| format | Article |
| id | doaj.art-52317e04c5b64cf9ba76d0b116c9d0d4 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T00:27:37Z |
| publishDate | 2023-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-52317e04c5b64cf9ba76d0b116c9d0d42023-03-15T05:49:14ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-02-01172ZD09ZD1210.7860/JCDR/2023/61118.17500Granular Cell Ameloblastoma: A Rare Case Report and Literature ReviewSamiha Jameel Ahmed Khan0Madhuri Gawande1Alka Hande2Swati Patil3Archana Sonone4Postgraduate student, Department of Oral Pathology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.Professor and Head, Department of Oral Pathology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.Professor, Department of Oral Pathology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.Associate Professor, Department of Oral Pathology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.Assistant Professor, Department of Oral Pathology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.Ameloblastomas are rare, benign, aggressive neoplasms of odontogenic epithelial origin. Among the various types of ameloblastomas, granular cell ameloblastoma is rare and accounts for less than 5% of the total. Granular cells are epithelial in origin. The distinct histopathological characteristics of granular cells are associated with high lysosomal content in tumour cells cytoplasm. A 43-year-old female patient presented with a painful swelling on the left-side of the jaw. The diagnosis was based on clinical, radiological and histopathological examination. A complete surgical resection was done. Histopathology showed features of granular cell ameloblastoma. The operative procedure was uneventful. Granular cell ameloblastoma has a high tendency for recurrence. Around 33.3% recurrence is reported, according to various studies. This rate is much higher than other subtypes of ameloblastoma, which are more common. Hence, it is essential to provide appropriate surgical treatment on time to prevent tumour recurrence and metastasis.This case report aims to highlight the unique features of granular cell ameloblastoma, distinguishing it from other subtypes and discussing the pathogenesis and treatment modalities.https://jcdr.net/articles/PDF/17500/61118_CE[Ra1]_F(IS)_PF1(AKA_OM)_PN(SHU).pdflocallysosomesneoplasm recurrence |
| spellingShingle | Samiha Jameel Ahmed Khan Madhuri Gawande Alka Hande Swati Patil Archana Sonone Granular Cell Ameloblastoma: A Rare Case Report and Literature Review Journal of Clinical and Diagnostic Research local lysosomes neoplasm recurrence |
| title | Granular Cell Ameloblastoma: A Rare Case Report and Literature Review |
| title_full | Granular Cell Ameloblastoma: A Rare Case Report and Literature Review |
| title_fullStr | Granular Cell Ameloblastoma: A Rare Case Report and Literature Review |
| title_full_unstemmed | Granular Cell Ameloblastoma: A Rare Case Report and Literature Review |
| title_short | Granular Cell Ameloblastoma: A Rare Case Report and Literature Review |
| title_sort | granular cell ameloblastoma a rare case report and literature review |
| topic | local lysosomes neoplasm recurrence |
| url | https://jcdr.net/articles/PDF/17500/61118_CE[Ra1]_F(IS)_PF1(AKA_OM)_PN(SHU).pdf |
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