Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?

Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?

The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many physiological processes. Here we studied the phenotype of TRAF6[L74H] knock-in mice which are devoid of TRAF6 E3 ligase activity in every cell of the body, but express normal levels of the TRAF6 protein. Remarkably, TRA...

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Bibliographic Details
Main Authors: Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L Scudamore, Alan R Prescott, Philip Cohen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0263151

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https://doi.org/10.1371/journal.pone.0263151

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