Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?
The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many physiological processes. Here we studied the phenotype of TRAF6[L74H] knock-in mice which are devoid of TRAF6 E3 ligase activity in every cell of the body, but express normal levels of the TRAF6 protein. Remarkably, TRA...
Main Authors: | Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L Scudamore, Alan R Prescott, Philip Cohen |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0263151 |
Similar Items
-
Comparison of Target Recognition by TRAF1 and TRAF2
by: Chang Min Kim, et al.
Published: (2020-04-01) -
Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice
by: Philip Cohen, et al.
Published: (2023-01-01) -
TRAF6 is a nexus for TLR‐STAT1 crosstalk
by: Bezbradica, J, et al.
Published: (2014) -
Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis.
by: Mabilleau, G, et al.
Published: (2011) -
Regularization Through Feature Knock Out
by: Wolf, Lior, et al.
Published: (2005)