Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria
Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases. These infections are extremely challenging to treat due to multidru...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/8/450 |
| _version_ | 1797561219192717312 |
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| author | Suresh Mickymaray Faiz Abdulaziz Alfaiz Anand Paramasivam |
| author_facet | Suresh Mickymaray Faiz Abdulaziz Alfaiz Anand Paramasivam |
| author_sort | Suresh Mickymaray |
| collection | DOAJ |
| description | Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases. These infections are extremely challenging to treat due to multidrug resistance, which encompasses the classical and existing antituberculosis agents. Hence, current studies are aimed to appraise the antimycobacterial activity of flavonoids against NTM, their capacity to synergize with pharmacological agents and their ability to block virulence. Flavonoids have potential antimycobacterial effects at minor quantities by themselves or in synergistic combinations. A cocktail of flavonoids used with existing antimycobacterial agents is a strategy to lessen side effects. The present review focuses on recent studies on naturally occurring flavonoids and their antimycobacterial effects, underlying mechanisms and synergistic effects in a cocktail with traditional agents. |
| first_indexed | 2024-03-10T18:11:01Z |
| format | Article |
| id | doaj.art-52321d7e42b440149c87627e9484873f |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T18:11:01Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-52321d7e42b440149c87627e9484873f2023-11-20T08:04:01ZengMDPI AGAntibiotics2079-63822020-07-019845010.3390/antibiotics9080450Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous MycobacteriaSuresh Mickymaray0Faiz Abdulaziz Alfaiz1Anand Paramasivam2Department of Biology, College of Science, Al-Zulfi, Majmaah University, Majmaah 11952, Riyadh Region, Saudi ArabiaDepartment of Biology, College of Science, Al-Zulfi, Majmaah University, Majmaah 11952, Riyadh Region, Saudi ArabiaDepartment of Basic Medical Sciences, College of Dentistry, Al-Zulfi, Majmaah University, Majmaah 11952, Riyadh Region, Saudi ArabiaNontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases. These infections are extremely challenging to treat due to multidrug resistance, which encompasses the classical and existing antituberculosis agents. Hence, current studies are aimed to appraise the antimycobacterial activity of flavonoids against NTM, their capacity to synergize with pharmacological agents and their ability to block virulence. Flavonoids have potential antimycobacterial effects at minor quantities by themselves or in synergistic combinations. A cocktail of flavonoids used with existing antimycobacterial agents is a strategy to lessen side effects. The present review focuses on recent studies on naturally occurring flavonoids and their antimycobacterial effects, underlying mechanisms and synergistic effects in a cocktail with traditional agents.https://www.mdpi.com/2079-6382/9/8/450nontuberculous mycobacteriaflavonoidssynergistic actionunderlying mechanisms |
| spellingShingle | Suresh Mickymaray Faiz Abdulaziz Alfaiz Anand Paramasivam Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria Antibiotics nontuberculous mycobacteria flavonoids synergistic action underlying mechanisms |
| title | Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria |
| title_full | Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria |
| title_fullStr | Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria |
| title_full_unstemmed | Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria |
| title_short | Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria |
| title_sort | efficacy and mechanisms of flavonoids against the emerging opportunistic nontuberculous mycobacteria |
| topic | nontuberculous mycobacteria flavonoids synergistic action underlying mechanisms |
| url | https://www.mdpi.com/2079-6382/9/8/450 |
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