Oxytocin-Induced Changes in Intrinsic Network Connectivity in Cocaine Use Disorder: Modulation by Gender, Childhood Trauma, and Years of Use
Cocaine use disorder (CUD) is a major public health concern with devastating social, economic, and mental health implications. A better understanding of the underlying neurobiology and phenotypic variations in individuals with CUD is necessary for the development of effective and targeted treatments...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00502/full |
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| author | Jane E. Joseph Brandon K. Vaughan Christopher C. Camp Nathaniel L. Baker Brian J. Sherman Megan Moran-Santa Maria Aimee McRae-Clark Aimee McRae-Clark Kathleen T. Brady Kathleen T. Brady |
| author_facet | Jane E. Joseph Brandon K. Vaughan Christopher C. Camp Nathaniel L. Baker Brian J. Sherman Megan Moran-Santa Maria Aimee McRae-Clark Aimee McRae-Clark Kathleen T. Brady Kathleen T. Brady |
| author_sort | Jane E. Joseph |
| collection | DOAJ |
| description | Cocaine use disorder (CUD) is a major public health concern with devastating social, economic, and mental health implications. A better understanding of the underlying neurobiology and phenotypic variations in individuals with CUD is necessary for the development of effective and targeted treatments. In this study, 39 women and 54 men with CUD completed a 6-min resting-state functional magnetic resonance imaging scan after intranasal oxytocin (OXY) or placebo administration. Graph-theory network analysis was used to quantify functional connectivity changes caused by OXY in striatum, anterior cingulate cortex (ACC), insula, and amygdala nodes of interest. OXY increased connectivity in the right ACC and left amygdala in males, whereas OXY increased connectivity in the right ACC and right accumbens in females. Machine learning was then used to associate treatment response (placebo minus OXY) in nodes of interest with years of cocaine use and severity of childhood trauma separately for males and females. Childhood trauma and years of cocaine use were associated with OXY-induced changes in ACC connectivity for both men and women, but connectivity changes in the amygdala were associated with years of cocaine use in men and connectivity changes in the right insula were associated with years of cocaine use in women. These findings suggest that salience network nodes (ACC and insula) are potential OXY treatment targets in CUD, with the amygdala as a treatment target for men and the accumbens as a treatment target for women. |
| first_indexed | 2024-12-21T05:51:50Z |
| format | Article |
| id | doaj.art-5232407f1f304e61a5f71ae4fcaba1d3 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-21T05:51:50Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-5232407f1f304e61a5f71ae4fcaba1d32022-12-21T19:13:57ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-07-011010.3389/fpsyt.2019.00502446129Oxytocin-Induced Changes in Intrinsic Network Connectivity in Cocaine Use Disorder: Modulation by Gender, Childhood Trauma, and Years of UseJane E. Joseph0Brandon K. Vaughan1Christopher C. Camp2Nathaniel L. Baker3Brian J. Sherman4Megan Moran-Santa Maria5Aimee McRae-Clark6Aimee McRae-Clark7Kathleen T. Brady8Kathleen T. Brady9Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United StatesRalph H. Johnson VA Medical Center, Charleston, SC, United StatesDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United StatesRalph H. Johnson VA Medical Center, Charleston, SC, United StatesCocaine use disorder (CUD) is a major public health concern with devastating social, economic, and mental health implications. A better understanding of the underlying neurobiology and phenotypic variations in individuals with CUD is necessary for the development of effective and targeted treatments. In this study, 39 women and 54 men with CUD completed a 6-min resting-state functional magnetic resonance imaging scan after intranasal oxytocin (OXY) or placebo administration. Graph-theory network analysis was used to quantify functional connectivity changes caused by OXY in striatum, anterior cingulate cortex (ACC), insula, and amygdala nodes of interest. OXY increased connectivity in the right ACC and left amygdala in males, whereas OXY increased connectivity in the right ACC and right accumbens in females. Machine learning was then used to associate treatment response (placebo minus OXY) in nodes of interest with years of cocaine use and severity of childhood trauma separately for males and females. Childhood trauma and years of cocaine use were associated with OXY-induced changes in ACC connectivity for both men and women, but connectivity changes in the amygdala were associated with years of cocaine use in men and connectivity changes in the right insula were associated with years of cocaine use in women. These findings suggest that salience network nodes (ACC and insula) are potential OXY treatment targets in CUD, with the amygdala as a treatment target for men and the accumbens as a treatment target for women.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00502/fullconnectomegraph-theoryresting stategender differencesfunctional connectivity |
| spellingShingle | Jane E. Joseph Brandon K. Vaughan Christopher C. Camp Nathaniel L. Baker Brian J. Sherman Megan Moran-Santa Maria Aimee McRae-Clark Aimee McRae-Clark Kathleen T. Brady Kathleen T. Brady Oxytocin-Induced Changes in Intrinsic Network Connectivity in Cocaine Use Disorder: Modulation by Gender, Childhood Trauma, and Years of Use Frontiers in Psychiatry connectome graph-theory resting state gender differences functional connectivity |
| title | Oxytocin-Induced Changes in Intrinsic Network Connectivity in Cocaine Use Disorder: Modulation by Gender, Childhood Trauma, and Years of Use |
| title_full | Oxytocin-Induced Changes in Intrinsic Network Connectivity in Cocaine Use Disorder: Modulation by Gender, Childhood Trauma, and Years of Use |
| title_fullStr | Oxytocin-Induced Changes in Intrinsic Network Connectivity in Cocaine Use Disorder: Modulation by Gender, Childhood Trauma, and Years of Use |
| title_full_unstemmed | Oxytocin-Induced Changes in Intrinsic Network Connectivity in Cocaine Use Disorder: Modulation by Gender, Childhood Trauma, and Years of Use |
| title_short | Oxytocin-Induced Changes in Intrinsic Network Connectivity in Cocaine Use Disorder: Modulation by Gender, Childhood Trauma, and Years of Use |
| title_sort | oxytocin induced changes in intrinsic network connectivity in cocaine use disorder modulation by gender childhood trauma and years of use |
| topic | connectome graph-theory resting state gender differences functional connectivity |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00502/full |
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