Three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy in carcinoma cervix
Background: Cervical cancer is the most common gynecological cancer among Indian women. 3D-CRT treatment is associated with more acute and late toxicities, because of close proximity of bladder and rectum to the cervix. The newer technique like IMRT is associated with less toxicities. Our study is t...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
| Series: | Journal of Clinical and Scientific Research |
| Subjects: | |
| Online Access: | http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2018;volume=7;issue=3;spage=114;epage=118;aulast=Badiginchala |
| _version_ | 1811295522186592256 |
|---|---|
| author | Revathi Badiginchala Swapna Jilla B V Subramanian Prana Bandhu Das Archana Prathipati G Sanjeeva Kumar |
| author_facet | Revathi Badiginchala Swapna Jilla B V Subramanian Prana Bandhu Das Archana Prathipati G Sanjeeva Kumar |
| author_sort | Revathi Badiginchala |
| collection | DOAJ |
| description | Background: Cervical cancer is the most common gynecological cancer among Indian women. 3D-CRT treatment is associated with more acute and late toxicities, because of close proximity of bladder and rectum to the cervix. The newer technique like IMRT is associated with less toxicities. Our study is to compare 3D-CRT and IMRT in terms of dosimetric parameters, toxicities and clinical outcomes.
Methods: From February 2015 to July 2016 total 40 newly diagnosed locally advanced cervical carcinoma patients were treated with concurrent chemo radiotherapy with weekly cisplatin. Those patients were randomized to arm A - 3D-CRT and arm B - IMRT.
Results: The dosimetric parameters of the bladder, rectum, bowel bag, and pelvic bone marrow were significantly decreased in the IMRT arm as compared to 3DCRT arm except for V30, V50 of bowel bag and V50 of pelvic bone marrow. The acute and late toxicities were similar among both arms. All the patients were assessed for treatment response at 6 weeks after completion of the treatment. All achieved complete clinical response. Out of 40 patients only one had brain metastasis after a median follow up of 18 months.
Conclusions: Though IMRT showed dosimetric reduction compared to 3D-CRT but it did not showed any clinical benefit. At present scenario in developing countries like India where the cancer centers are over loaded with the carcinoma cervix cases can be treated with the 3D-CRT technique without compromising clinical outcomes. |
| first_indexed | 2024-04-13T05:33:49Z |
| format | Article |
| id | doaj.art-5232f60ba1c048cf9f0c8f4516c65f6d |
| institution | Directory Open Access Journal |
| issn | 2277-5706 2277-8357 |
| language | English |
| last_indexed | 2024-04-13T05:33:49Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Scientific Research |
| spelling | doaj.art-5232f60ba1c048cf9f0c8f4516c65f6d2022-12-22T03:00:20ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572018-01-017311411810.4103/JCSR.JCSR_46_18Three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy in carcinoma cervixRevathi BadiginchalaSwapna JillaB V SubramanianPrana Bandhu DasArchana PrathipatiG Sanjeeva KumarBackground: Cervical cancer is the most common gynecological cancer among Indian women. 3D-CRT treatment is associated with more acute and late toxicities, because of close proximity of bladder and rectum to the cervix. The newer technique like IMRT is associated with less toxicities. Our study is to compare 3D-CRT and IMRT in terms of dosimetric parameters, toxicities and clinical outcomes. Methods: From February 2015 to July 2016 total 40 newly diagnosed locally advanced cervical carcinoma patients were treated with concurrent chemo radiotherapy with weekly cisplatin. Those patients were randomized to arm A - 3D-CRT and arm B - IMRT. Results: The dosimetric parameters of the bladder, rectum, bowel bag, and pelvic bone marrow were significantly decreased in the IMRT arm as compared to 3DCRT arm except for V30, V50 of bowel bag and V50 of pelvic bone marrow. The acute and late toxicities were similar among both arms. All the patients were assessed for treatment response at 6 weeks after completion of the treatment. All achieved complete clinical response. Out of 40 patients only one had brain metastasis after a median follow up of 18 months. Conclusions: Though IMRT showed dosimetric reduction compared to 3D-CRT but it did not showed any clinical benefit. At present scenario in developing countries like India where the cancer centers are over loaded with the carcinoma cervix cases can be treated with the 3D-CRT technique without compromising clinical outcomes.http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2018;volume=7;issue=3;spage=114;epage=118;aulast=Badiginchalacarcinoma cervixintensity-modulated radiotherapythree-dimensional conformal radiotherapy |
| spellingShingle | Revathi Badiginchala Swapna Jilla B V Subramanian Prana Bandhu Das Archana Prathipati G Sanjeeva Kumar Three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy in carcinoma cervix Journal of Clinical and Scientific Research carcinoma cervix intensity-modulated radiotherapy three-dimensional conformal radiotherapy |
| title | Three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy in carcinoma cervix |
| title_full | Three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy in carcinoma cervix |
| title_fullStr | Three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy in carcinoma cervix |
| title_full_unstemmed | Three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy in carcinoma cervix |
| title_short | Three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy in carcinoma cervix |
| title_sort | three dimensional conformal radiotherapy versus intensity modulated radiotherapy in carcinoma cervix |
| topic | carcinoma cervix intensity-modulated radiotherapy three-dimensional conformal radiotherapy |
| url | http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2018;volume=7;issue=3;spage=114;epage=118;aulast=Badiginchala |
| work_keys_str_mv | AT revathibadiginchala threedimensionalconformalradiotherapyversusintensitymodulatedradiotherapyincarcinomacervix AT swapnajilla threedimensionalconformalradiotherapyversusintensitymodulatedradiotherapyincarcinomacervix AT bvsubramanian threedimensionalconformalradiotherapyversusintensitymodulatedradiotherapyincarcinomacervix AT pranabandhudas threedimensionalconformalradiotherapyversusintensitymodulatedradiotherapyincarcinomacervix AT archanaprathipati threedimensionalconformalradiotherapyversusintensitymodulatedradiotherapyincarcinomacervix AT gsanjeevakumar threedimensionalconformalradiotherapyversusintensitymodulatedradiotherapyincarcinomacervix |