Comparative study of six-month and eight-month treatment of new smear positive tuberculosis cases at a tertiary health facility in Enugu, South-Eastern Nigeria
Introduction: Factors that affect tuberculosis (TB) treatment outcomes are important and should be investigated to achieve the targets of TB control program. Aims and Objectives: The aim of this study was to compare treatment outcomes of new smear positive TB patients treated for six months with tho...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | International Journal of Medicine and Health Development |
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| Online Access: | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2019;volume=24;issue=2;spage=78;epage=84;aulast=Omotowo |
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| author | Babatunde I Omotowo Ijeoma Itanyi Edmund O Ndibuagu Chuka C Agunwa Ikechukwu E Obi Arthur C Idoko Anne C Ndu |
| author_facet | Babatunde I Omotowo Ijeoma Itanyi Edmund O Ndibuagu Chuka C Agunwa Ikechukwu E Obi Arthur C Idoko Anne C Ndu |
| author_sort | Babatunde I Omotowo |
| collection | DOAJ |
| description | Introduction: Factors that affect tuberculosis (TB) treatment outcomes are important and should be investigated to achieve the targets of TB control program. Aims and Objectives: The aim of this study was to compare treatment outcomes of new smear positive TB patients treated for six months with those treated for eight months. Materials and Methods: A retrospective study of 600 new smear-positive TB patients was carried out. The data were analyzed using Stata version 22 (SPSS Inc., Chicago, Illinois, USA), and the values of P < 0.05 were considered statistically significant. Binary logistic regression was used to identify factors that influenced treatment outcomes. Results: Overall, a higher proportion of patients (78.6%) who were treated for six months had successful treatment outcomes as compared with those treated for eight months 64.4% (P = < 0.001, OR = 2.03, CI = 1.41–2.91). After adjusting for confounders, sex (P = 0.040, AOR = 0.65, CI = 0.44–0.98), treatment duration (P < 0.001, AOR = 2.27, CI = 1.53–3.39), and pretreatment weight (P = 0.007, AOR = 1.28, CI = 1.07–1.52) independently predicted treatment outcome. Conclusion: The treatment success rate was better among the patients treated for six-month duration than those treated for eight-month duration. The current six-month regimen recommended by WHO should be maintained. Loss to follow-up and TB/HIV coinfection management should be improved. |
| first_indexed | 2024-04-11T06:45:41Z |
| format | Article |
| id | doaj.art-5234b7589ccf4b5297032920386d4117 |
| institution | Directory Open Access Journal |
| issn | 2635-3695 |
| language | English |
| last_indexed | 2024-04-11T06:45:41Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Medicine and Health Development |
| spelling | doaj.art-5234b7589ccf4b5297032920386d41172022-12-22T04:39:22ZengWolters Kluwer Medknow PublicationsInternational Journal of Medicine and Health Development2635-36952019-01-01242788410.4103/ijmh.IJMH_24_19Comparative study of six-month and eight-month treatment of new smear positive tuberculosis cases at a tertiary health facility in Enugu, South-Eastern NigeriaBabatunde I OmotowoIjeoma ItanyiEdmund O NdibuaguChuka C AgunwaIkechukwu E ObiArthur C IdokoAnne C NduIntroduction: Factors that affect tuberculosis (TB) treatment outcomes are important and should be investigated to achieve the targets of TB control program. Aims and Objectives: The aim of this study was to compare treatment outcomes of new smear positive TB patients treated for six months with those treated for eight months. Materials and Methods: A retrospective study of 600 new smear-positive TB patients was carried out. The data were analyzed using Stata version 22 (SPSS Inc., Chicago, Illinois, USA), and the values of P < 0.05 were considered statistically significant. Binary logistic regression was used to identify factors that influenced treatment outcomes. Results: Overall, a higher proportion of patients (78.6%) who were treated for six months had successful treatment outcomes as compared with those treated for eight months 64.4% (P = < 0.001, OR = 2.03, CI = 1.41–2.91). After adjusting for confounders, sex (P = 0.040, AOR = 0.65, CI = 0.44–0.98), treatment duration (P < 0.001, AOR = 2.27, CI = 1.53–3.39), and pretreatment weight (P = 0.007, AOR = 1.28, CI = 1.07–1.52) independently predicted treatment outcome. Conclusion: The treatment success rate was better among the patients treated for six-month duration than those treated for eight-month duration. The current six-month regimen recommended by WHO should be maintained. Loss to follow-up and TB/HIV coinfection management should be improved.http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2019;volume=24;issue=2;spage=78;epage=84;aulast=Omotowoeight monthsnigeriasix monthssmear positivetreatment outcomestuberculosis |
| spellingShingle | Babatunde I Omotowo Ijeoma Itanyi Edmund O Ndibuagu Chuka C Agunwa Ikechukwu E Obi Arthur C Idoko Anne C Ndu Comparative study of six-month and eight-month treatment of new smear positive tuberculosis cases at a tertiary health facility in Enugu, South-Eastern Nigeria International Journal of Medicine and Health Development eight months nigeria six months smear positive treatment outcomes tuberculosis |
| title | Comparative study of six-month and eight-month treatment of new smear positive tuberculosis cases at a tertiary health facility in Enugu, South-Eastern Nigeria |
| title_full | Comparative study of six-month and eight-month treatment of new smear positive tuberculosis cases at a tertiary health facility in Enugu, South-Eastern Nigeria |
| title_fullStr | Comparative study of six-month and eight-month treatment of new smear positive tuberculosis cases at a tertiary health facility in Enugu, South-Eastern Nigeria |
| title_full_unstemmed | Comparative study of six-month and eight-month treatment of new smear positive tuberculosis cases at a tertiary health facility in Enugu, South-Eastern Nigeria |
| title_short | Comparative study of six-month and eight-month treatment of new smear positive tuberculosis cases at a tertiary health facility in Enugu, South-Eastern Nigeria |
| title_sort | comparative study of six month and eight month treatment of new smear positive tuberculosis cases at a tertiary health facility in enugu south eastern nigeria |
| topic | eight months nigeria six months smear positive treatment outcomes tuberculosis |
| url | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2019;volume=24;issue=2;spage=78;epage=84;aulast=Omotowo |
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