Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab
Abstract Behcet's disease (BD) is a multisystem immune‐mediated inflammatory disorder that occasionally involves the gastrointestinal tract. Reports on gastrointestinal involvement of BD are relatively rare, of which gastroduodenal involvement is particularly rare. Endoscopic features of gastro...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | DEN Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/deo2.196 |
| _version_ | 1827957594829881344 |
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| author | Shun Fujiwara Ami Kawamoto Maiko Motobayashi Shuji Hibiya Kento Takenaka Hiromichi Shimizu Eiko Saito Toshimitsu Fujii Masakazu Nagahori Daisuke Kawata Natsuka Umezawa Tadashi Hosoya Shinsuke Yasuda Kazuo Ohtsuka Ryuichi Okamoto |
| author_facet | Shun Fujiwara Ami Kawamoto Maiko Motobayashi Shuji Hibiya Kento Takenaka Hiromichi Shimizu Eiko Saito Toshimitsu Fujii Masakazu Nagahori Daisuke Kawata Natsuka Umezawa Tadashi Hosoya Shinsuke Yasuda Kazuo Ohtsuka Ryuichi Okamoto |
| author_sort | Shun Fujiwara |
| collection | DOAJ |
| description | Abstract Behcet's disease (BD) is a multisystem immune‐mediated inflammatory disorder that occasionally involves the gastrointestinal tract. Reports on gastrointestinal involvement of BD are relatively rare, of which gastroduodenal involvement is particularly rare. Endoscopic features of gastroduodenal lesions are unknown, and treatment strategies have not been established. In this report, we present the case of a 72‐year‐old female with gastrointestinal BD who presented with extensive gastroduodenal ulcers and hematemesis that were resistant to colchicine and corticosteroid treatment, which were subsequently successfully treated with infliximab. We also review the current literature on the gastroduodenal involvement of BD. Although rare, the case highlights the importance of being aware of upper gastrointestinal manifestations of BD, as well as demonstrating the potential of infliximab to treat corticosteroid‐resistant cases. |
| first_indexed | 2024-04-09T15:22:27Z |
| format | Article |
| id | doaj.art-5234bd5cd96343769047e5654410e61d |
| institution | Directory Open Access Journal |
| issn | 2692-4609 |
| language | English |
| last_indexed | 2024-04-09T15:22:27Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj.art-5234bd5cd96343769047e5654410e61d2023-04-29T05:12:58ZengWileyDEN Open2692-46092023-04-0131n/an/a10.1002/deo2.196Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximabShun Fujiwara0Ami Kawamoto1Maiko Motobayashi2Shuji Hibiya3Kento Takenaka4Hiromichi Shimizu5Eiko Saito6Toshimitsu Fujii7Masakazu Nagahori8Daisuke Kawata9Natsuka Umezawa10Tadashi Hosoya11Shinsuke Yasuda12Kazuo Ohtsuka13Ryuichi Okamoto14Department of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanDepartment of Rheumatology Tokyo Medical and Dental University Tokyo JapanDepartment of Rheumatology Tokyo Medical and Dental University Tokyo JapanDepartment of Rheumatology Tokyo Medical and Dental University Tokyo JapanDepartment of Rheumatology Tokyo Medical and Dental University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo JapanAbstract Behcet's disease (BD) is a multisystem immune‐mediated inflammatory disorder that occasionally involves the gastrointestinal tract. Reports on gastrointestinal involvement of BD are relatively rare, of which gastroduodenal involvement is particularly rare. Endoscopic features of gastroduodenal lesions are unknown, and treatment strategies have not been established. In this report, we present the case of a 72‐year‐old female with gastrointestinal BD who presented with extensive gastroduodenal ulcers and hematemesis that were resistant to colchicine and corticosteroid treatment, which were subsequently successfully treated with infliximab. We also review the current literature on the gastroduodenal involvement of BD. Although rare, the case highlights the importance of being aware of upper gastrointestinal manifestations of BD, as well as demonstrating the potential of infliximab to treat corticosteroid‐resistant cases.https://doi.org/10.1002/deo2.196Behcet's diseaseduodenal ulcersgastric ulcershemorrhageinfliximab |
| spellingShingle | Shun Fujiwara Ami Kawamoto Maiko Motobayashi Shuji Hibiya Kento Takenaka Hiromichi Shimizu Eiko Saito Toshimitsu Fujii Masakazu Nagahori Daisuke Kawata Natsuka Umezawa Tadashi Hosoya Shinsuke Yasuda Kazuo Ohtsuka Ryuichi Okamoto Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab DEN Open Behcet's disease duodenal ulcers gastric ulcers hemorrhage infliximab |
| title | Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab |
| title_full | Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab |
| title_fullStr | Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab |
| title_full_unstemmed | Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab |
| title_short | Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab |
| title_sort | hemorrhagic gastric ulcer in a patient with behcet s disease successfully treated with infliximab |
| topic | Behcet's disease duodenal ulcers gastric ulcers hemorrhage infliximab |
| url | https://doi.org/10.1002/deo2.196 |
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