Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population
Abstract Background Cholesterol has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence about crucial requirement of neuron membrane cholesterol in the organization and function of the 5-HT1A serotonin receptor. For this, low cholesterol level ha...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12888-018-1596-z |
| _version_ | 1818068158271979520 |
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| author | Marcela Segoviano-Mendoza Manuel Cárdenas-de la Cruz José Salas-Pacheco Fernando Vázquez-Alaniz Osmel La Llave-León Francisco Castellanos-Juárez Jazmín Méndez-Hernández Marcelo Barraza-Salas Ernesto Miranda-Morales Oscar Arias-Carrión Edna Méndez-Hernández |
| author_facet | Marcela Segoviano-Mendoza Manuel Cárdenas-de la Cruz José Salas-Pacheco Fernando Vázquez-Alaniz Osmel La Llave-León Francisco Castellanos-Juárez Jazmín Méndez-Hernández Marcelo Barraza-Salas Ernesto Miranda-Morales Oscar Arias-Carrión Edna Méndez-Hernández |
| author_sort | Marcela Segoviano-Mendoza |
| collection | DOAJ |
| description | Abstract Background Cholesterol has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence about crucial requirement of neuron membrane cholesterol in the organization and function of the 5-HT1A serotonin receptor. For this, low cholesterol level has been reported to be associated with depression and suicidality. However there have been inconsistent reports about this finding and the exact relationship between these factors remains controversial. Therefore, we investigated the link between serum cholesterol and its fractions with depression disorder and suicide attempt in 467 adult subjects in Mexican mestizo population. Methods Plasma levels of total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) were determined in 261 MDD patients meeting the DSM-5 criteria for major depressive disorder (MDD), 59 of whom had undergone an episode of suicide attempt, and 206 healthy controls. Results A significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglyceride serum levels was observed in the groups of MDD patients and suicide attempt compared to those without suicidal behavior (p < 0.05). After adjusting for covariates, lower cholesterol levels were significantly associated with MDD (OR 4.229 CI 95% 2.555 – 7.000, p<.001) and suicide attempt (OR 5.540 CI 95% 2.825 – 10.866, p<.001) Conclusions These results support the hypothesis that lower levels of cholesterol are associated with mood disorders like MDD and suicidal behavior. More mechanistic studies are needed to further explain this association. |
| first_indexed | 2024-12-10T15:35:08Z |
| format | Article |
| id | doaj.art-5235a2a74ddd4f5f9bdfe0b09f37e234 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-10T15:35:08Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-5235a2a74ddd4f5f9bdfe0b09f37e2342022-12-22T01:43:15ZengBMCBMC Psychiatry1471-244X2018-01-011811710.1186/s12888-018-1596-zHypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican populationMarcela Segoviano-Mendoza0Manuel Cárdenas-de la Cruz1José Salas-Pacheco2Fernando Vázquez-Alaniz3Osmel La Llave-León4Francisco Castellanos-Juárez5Jazmín Méndez-Hernández6Marcelo Barraza-Salas7Ernesto Miranda-Morales8Oscar Arias-Carrión9Edna Méndez-Hernández10Instituto de Investigación Científica, Universidad Juárez del Estado de DurangoInstituto de Investigación Científica, Universidad Juárez del Estado de DurangoInstituto de Investigación Científica, Universidad Juárez del Estado de DurangoHospital General 450, Servicios de Salud de SaludInstituto de Investigación Científica, Universidad Juárez del Estado de DurangoInstituto de Investigación Científica, Universidad Juárez del Estado de DurangoDepartamento de Biotecnología, Universidad Autónoma MetropolitanaFacultad de Ciencias Químicas, Universidad Juárez del Estado de DurangoInstituto de Investigación Científica, Universidad Juárez del Estado de DurangoUnidad de Trastornos del Movimiento y Sueño (TMS), Hospital General Dr. Manuel Gea GonzálezInstituto de Investigación Científica, Universidad Juárez del Estado de DurangoAbstract Background Cholesterol has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence about crucial requirement of neuron membrane cholesterol in the organization and function of the 5-HT1A serotonin receptor. For this, low cholesterol level has been reported to be associated with depression and suicidality. However there have been inconsistent reports about this finding and the exact relationship between these factors remains controversial. Therefore, we investigated the link between serum cholesterol and its fractions with depression disorder and suicide attempt in 467 adult subjects in Mexican mestizo population. Methods Plasma levels of total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) were determined in 261 MDD patients meeting the DSM-5 criteria for major depressive disorder (MDD), 59 of whom had undergone an episode of suicide attempt, and 206 healthy controls. Results A significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglyceride serum levels was observed in the groups of MDD patients and suicide attempt compared to those without suicidal behavior (p < 0.05). After adjusting for covariates, lower cholesterol levels were significantly associated with MDD (OR 4.229 CI 95% 2.555 – 7.000, p<.001) and suicide attempt (OR 5.540 CI 95% 2.825 – 10.866, p<.001) Conclusions These results support the hypothesis that lower levels of cholesterol are associated with mood disorders like MDD and suicidal behavior. More mechanistic studies are needed to further explain this association.http://link.springer.com/article/10.1186/s12888-018-1596-zSuicide attemptdepressioncholesterol |
| spellingShingle | Marcela Segoviano-Mendoza Manuel Cárdenas-de la Cruz José Salas-Pacheco Fernando Vázquez-Alaniz Osmel La Llave-León Francisco Castellanos-Juárez Jazmín Méndez-Hernández Marcelo Barraza-Salas Ernesto Miranda-Morales Oscar Arias-Carrión Edna Méndez-Hernández Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population BMC Psychiatry Suicide attempt depression cholesterol |
| title | Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population |
| title_full | Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population |
| title_fullStr | Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population |
| title_full_unstemmed | Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population |
| title_short | Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population |
| title_sort | hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in northern mexican population |
| topic | Suicide attempt depression cholesterol |
| url | http://link.springer.com/article/10.1186/s12888-018-1596-z |
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