The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfection
BackgroundUnder the wave of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) variant Omicron epidemic, the number of infectious cases has increased dramatically in Jilin Province, China since March 2022.The clinical features and severity of SARS-CoV-2 Omicron variant infection in tub...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1061879/full |
| _version_ | 1828089147113340928 |
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| author | Yang Wang Yanping Chen Lina Gu Lixin Lou Jian Zhang Kaiyu Zhang |
| author_facet | Yang Wang Yanping Chen Lina Gu Lixin Lou Jian Zhang Kaiyu Zhang |
| author_sort | Yang Wang |
| collection | DOAJ |
| description | BackgroundUnder the wave of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) variant Omicron epidemic, the number of infectious cases has increased dramatically in Jilin Province, China since March 2022.The clinical features and severity of SARS-CoV-2 Omicron variant infection in tuberculosis (TB) patients are not yet clear.MethodsData were obtained from 153 patients with the Omicron variant and TB coinfection and 153 non-TB COVID-19 patients who had been hospitalized at Changchun Infectious Disease Hospital from March to June 2022.ResultsAmong these coinfection patients, 17 patients showed COVID-19-related pneumonia on chest imaging and 11 were diagnosed with severe COVID-19. The median duration of SARS-CoV-2 clearance was 13 days. The negative conversion time was associated with age, COVID-19-related pneumonia and antibody IgG. A higher white blood cell count, a lower lymphocyte percentage, a higher CRP level, and a higher D-dimer level were found in the severe group. Age and increased PCT were individual risk factors for the severity of COVID-19. Compared with the non-TB patients, the coinfection patients had higher severity of COVID-19 and the elder coinfection patients had a longer negative conversion time.ConclusionThis study found an association between age, pneumonia, antibody IgG and RNA negative conversion time in COVID-19 and TB coinfection patients, and age and increased PCT were risk factors for the severity of COVID-19. |
| first_indexed | 2024-04-11T05:35:43Z |
| format | Article |
| id | doaj.art-5235c26e8a284b7d8f999b6cdceb15f9 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-11T05:35:43Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-5235c26e8a284b7d8f999b6cdceb15f92022-12-22T12:50:04ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-12-011310.3389/fmicb.2022.10618791061879The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfectionYang Wang0Yanping Chen1Lina Gu2Lixin Lou3Jian Zhang4Kaiyu Zhang5Center of Infectious Disease and Pathogen Biology, Department of Infectious Diseases, The First Hospital of Jilin University, Changchun, ChinaDepartment of Tuberculosis, Changchun Infectious Disease Hospital, Changchun, ChinaIntensive Care Unit, The First Hospital of Jilin University, Changchun, ChinaCenter of Infectious Disease and Pathogen Biology, Department of Infectious Diseases, The First Hospital of Jilin University, Changchun, ChinaDepartment of Infectious Diseases, Changchun Infectious Disease Hospital, Changchun, ChinaCenter of Infectious Disease and Pathogen Biology, Department of Infectious Diseases, The First Hospital of Jilin University, Changchun, ChinaBackgroundUnder the wave of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) variant Omicron epidemic, the number of infectious cases has increased dramatically in Jilin Province, China since March 2022.The clinical features and severity of SARS-CoV-2 Omicron variant infection in tuberculosis (TB) patients are not yet clear.MethodsData were obtained from 153 patients with the Omicron variant and TB coinfection and 153 non-TB COVID-19 patients who had been hospitalized at Changchun Infectious Disease Hospital from March to June 2022.ResultsAmong these coinfection patients, 17 patients showed COVID-19-related pneumonia on chest imaging and 11 were diagnosed with severe COVID-19. The median duration of SARS-CoV-2 clearance was 13 days. The negative conversion time was associated with age, COVID-19-related pneumonia and antibody IgG. A higher white blood cell count, a lower lymphocyte percentage, a higher CRP level, and a higher D-dimer level were found in the severe group. Age and increased PCT were individual risk factors for the severity of COVID-19. Compared with the non-TB patients, the coinfection patients had higher severity of COVID-19 and the elder coinfection patients had a longer negative conversion time.ConclusionThis study found an association between age, pneumonia, antibody IgG and RNA negative conversion time in COVID-19 and TB coinfection patients, and age and increased PCT were risk factors for the severity of COVID-19.https://www.frontiersin.org/articles/10.3389/fmicb.2022.1061879/fullCOVID-19tuberculosiscoinfectionepidemiologicalclinical characteristicsRNA negative conversion time |
| spellingShingle | Yang Wang Yanping Chen Lina Gu Lixin Lou Jian Zhang Kaiyu Zhang The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfection Frontiers in Microbiology COVID-19 tuberculosis coinfection epidemiological clinical characteristics RNA negative conversion time |
| title | The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfection |
| title_full | The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfection |
| title_fullStr | The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfection |
| title_full_unstemmed | The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfection |
| title_short | The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfection |
| title_sort | clinical characteristics and risk factors for severe covid 19 in patients with covid 19 and tuberculosis coinfection |
| topic | COVID-19 tuberculosis coinfection epidemiological clinical characteristics RNA negative conversion time |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1061879/full |
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