Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in Mexico
BackgroundCow's milk protein allergy (CMPA) is the leading cause of food allergy in infants and young children. An extensively hydrolyzed formula (eHF) is the first choice of dietary management, however, not all of them have similar peptide profiles and degree of hydrolysis. The aim of this ret...
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| Format: | Article |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2023.1073430/full |
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| author | Elizabeth Estrada Reyes Benjamín Zepeda Ortega Dominique ten Haaf Urszula Kudla Leilani Muhardi Denise L. Hofman Jeske H. J. Hageman Rosa E. Huerta Hernández |
| author_facet | Elizabeth Estrada Reyes Benjamín Zepeda Ortega Dominique ten Haaf Urszula Kudla Leilani Muhardi Denise L. Hofman Jeske H. J. Hageman Rosa E. Huerta Hernández |
| author_sort | Elizabeth Estrada Reyes |
| collection | DOAJ |
| description | BackgroundCow's milk protein allergy (CMPA) is the leading cause of food allergy in infants and young children. An extensively hydrolyzed formula (eHF) is the first choice of dietary management, however, not all of them have similar peptide profiles and degree of hydrolysis. The aim of this retrospective study was to investigate the use of two commercially available infant formulas in the clinical management of CMPA in Mexico in terms of symptoms' resolution and growth trajectories.MethodsMedical records of 79 subjects from four sites in Mexico were included to retrospectively evaluate the trajectory of atopic dermatitis, other symptoms of cow's milk protein allergy and growth outcomes. The study formulas were based on hydrolyzed whey protein (eHF-W) and hydrolyzed casein protein (eHF-C).ResultsMedical records of 79 patients were enrolled, 3 were excluded from analysis based on previous formula consumption. Seventy-six children with confirmed CMPA based on skin prick test and/or serum specific IgE levels were included in the analysis. 82% of patients (n = 65) consumed the eHF-C, reflecting the doctors' preference for formulas with a higher grade of hydrolysis and the high incidence of positive reactions to beta-lactoglobulin amongst subjects. During their first visit to the doctors, 55% of the subjects consuming the casein-based formula and 45% of subjects consuming the whey-based formula presented with mild or moderate dermatological symptoms. Other frequently reported symptoms included respiratory issues, enteropathies and colitis which improved during the consumption of both formulas. All CMPA-related symptoms showed improvement during formula consumption. During the period of retrospective observation, growth significantly improved for both groups.ConclusionConsumption of eHF-C and eHF-W effectively improved symptoms' resolution and growth outcomes among children with CMPA in Mexico. More preference was reported towards eHF-C due to its hydrolysate profile and lack of b-lactoglobulin.Trial registrationThe study was registered at ClinicalTrials.gov: NCT04596059. |
| first_indexed | 2024-04-10T19:36:29Z |
| format | Article |
| id | doaj.art-52376443c4424034a4ee50d8cf5d0dbb |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-04-10T19:36:29Z |
| publishDate | 2023-01-01 |
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| series | Frontiers in Allergy |
| spelling | doaj.art-52376443c4424034a4ee50d8cf5d0dbb2023-01-30T05:13:29ZengFrontiers Media S.A.Frontiers in Allergy2673-61012023-01-01410.3389/falgy.2023.10734301073430Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in MexicoElizabeth Estrada Reyes0Benjamín Zepeda Ortega1Dominique ten Haaf2Urszula Kudla3Leilani Muhardi4Denise L. Hofman5Jeske H. J. Hageman6Rosa E. Huerta Hernández7Consultorio Médico, Hospital Ángeles Metropolitano, Mexico City, MexicoClinica San Antonio, Metepec, MexicoFrieslandCampina, Amersfoort, NetherlandsFrieslandCampina, Amersfoort, NetherlandsFrieslandCampina, Amersfoort, NetherlandsFrieslandCampina, Amersfoort, NetherlandsFrieslandCampina, Amersfoort, NetherlandsClínica de Alergia Pediátrica, Pachua Hidalgo, MexicoBackgroundCow's milk protein allergy (CMPA) is the leading cause of food allergy in infants and young children. An extensively hydrolyzed formula (eHF) is the first choice of dietary management, however, not all of them have similar peptide profiles and degree of hydrolysis. The aim of this retrospective study was to investigate the use of two commercially available infant formulas in the clinical management of CMPA in Mexico in terms of symptoms' resolution and growth trajectories.MethodsMedical records of 79 subjects from four sites in Mexico were included to retrospectively evaluate the trajectory of atopic dermatitis, other symptoms of cow's milk protein allergy and growth outcomes. The study formulas were based on hydrolyzed whey protein (eHF-W) and hydrolyzed casein protein (eHF-C).ResultsMedical records of 79 patients were enrolled, 3 were excluded from analysis based on previous formula consumption. Seventy-six children with confirmed CMPA based on skin prick test and/or serum specific IgE levels were included in the analysis. 82% of patients (n = 65) consumed the eHF-C, reflecting the doctors' preference for formulas with a higher grade of hydrolysis and the high incidence of positive reactions to beta-lactoglobulin amongst subjects. During their first visit to the doctors, 55% of the subjects consuming the casein-based formula and 45% of subjects consuming the whey-based formula presented with mild or moderate dermatological symptoms. Other frequently reported symptoms included respiratory issues, enteropathies and colitis which improved during the consumption of both formulas. All CMPA-related symptoms showed improvement during formula consumption. During the period of retrospective observation, growth significantly improved for both groups.ConclusionConsumption of eHF-C and eHF-W effectively improved symptoms' resolution and growth outcomes among children with CMPA in Mexico. More preference was reported towards eHF-C due to its hydrolysate profile and lack of b-lactoglobulin.Trial registrationThe study was registered at ClinicalTrials.gov: NCT04596059.https://www.frontiersin.org/articles/10.3389/falgy.2023.1073430/fullcow's milk protein allergygrowthinfant formulahydrolysatesMexicoSCORAD |
| spellingShingle | Elizabeth Estrada Reyes Benjamín Zepeda Ortega Dominique ten Haaf Urszula Kudla Leilani Muhardi Denise L. Hofman Jeske H. J. Hageman Rosa E. Huerta Hernández Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in Mexico Frontiers in Allergy cow's milk protein allergy growth infant formula hydrolysates Mexico SCORAD |
| title | Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in Mexico |
| title_full | Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in Mexico |
| title_fullStr | Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in Mexico |
| title_full_unstemmed | Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in Mexico |
| title_short | Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in Mexico |
| title_sort | symptom s resolution and growth outcome of children with cow s milk protein allergy consuming two hydrolyzed formulas a retrospective study in mexico |
| topic | cow's milk protein allergy growth infant formula hydrolysates Mexico SCORAD |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2023.1073430/full |
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