Aspectos da imunologia da gravidez.
This review summarises the fundamental immunologic principles regarding the cellular and molecular relations involved with immune function in a normal gestation. During the past decades, more information has been gathered to explain these complex immunological mechanisms. These mechanisms include bo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
2007-11-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/865 |
| _version_ | 1797996905510207488 |
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| author | Sofia Sarafana Raquel Coelho Ana Neves José Costa Trindade |
| author_facet | Sofia Sarafana Raquel Coelho Ana Neves José Costa Trindade |
| author_sort | Sofia Sarafana |
| collection | DOAJ |
| description | This review summarises the fundamental immunologic principles regarding the cellular and molecular relations involved with immune function in a normal gestation. During the past decades, more information has been gathered to explain these complex immunological mechanisms. These mechanisms include both fetal factors such as trophoblast cell properties and altered MHC Class I expression and local maternal factors such as specialized uterine natural killer cells and a shifting of the T-helper cell cytokine profile from a type 1 to a type II array. Other novel immunomodulators are found to be expressed in the local uterine environment to aid in fetal survival. Increased knowledge about the immune relationship between the mother and the fetus permits not only a better understanding about pathological outcomes of pregnancy and gestational complications of autoimmune diseases but also the development of therapeutic approaches for solid organ transplantation. |
| first_indexed | 2024-04-11T10:24:45Z |
| format | Article |
| id | doaj.art-5237ae0d74d4447096552942cc8afc4a |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-11T10:24:45Z |
| publishDate | 2007-11-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-5237ae0d74d4447096552942cc8afc4a2022-12-22T04:29:38ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582007-11-0120410.20344/amp.865Aspectos da imunologia da gravidez.Sofia Sarafana0Raquel CoelhoAna NevesJosé Costa TrindadeUnidade de Imunoalergologia Pediátrica, Hospital Santa Maria, Lisboa.This review summarises the fundamental immunologic principles regarding the cellular and molecular relations involved with immune function in a normal gestation. During the past decades, more information has been gathered to explain these complex immunological mechanisms. These mechanisms include both fetal factors such as trophoblast cell properties and altered MHC Class I expression and local maternal factors such as specialized uterine natural killer cells and a shifting of the T-helper cell cytokine profile from a type 1 to a type II array. Other novel immunomodulators are found to be expressed in the local uterine environment to aid in fetal survival. Increased knowledge about the immune relationship between the mother and the fetus permits not only a better understanding about pathological outcomes of pregnancy and gestational complications of autoimmune diseases but also the development of therapeutic approaches for solid organ transplantation.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/865 |
| spellingShingle | Sofia Sarafana Raquel Coelho Ana Neves José Costa Trindade Aspectos da imunologia da gravidez. Acta Médica Portuguesa |
| title | Aspectos da imunologia da gravidez. |
| title_full | Aspectos da imunologia da gravidez. |
| title_fullStr | Aspectos da imunologia da gravidez. |
| title_full_unstemmed | Aspectos da imunologia da gravidez. |
| title_short | Aspectos da imunologia da gravidez. |
| title_sort | aspectos da imunologia da gravidez |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/865 |
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