Improved Solubility and Dissolution Rate of Ketoprofen by the Formation of Multicomponent Crystals with Tromethamine

Improved Solubility and Dissolution Rate of Ketoprofen by the Formation of Multicomponent Crystals with Tromethamine

This study aims to improve the dissolution rate of ketoprofen by preparing multicomponent crystals with tromethamine. The multicomponent crystals (equimolar ratio) of ketoprofen and tromethamine were prepared by the solvent co-evaporation method. The solid-state properties of the resulting powder we...

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Bibliographic Details
Main Authors: Lili Fitriani, Wahyu Alfath Firdaus, Wahyu Sidadang, Henni Rosaini, Okky Dwichandra Putra, Hironaga Oyama, Hidehiro Uekusa, Erizal Zaini
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Crystals
Subjects:
ketoprofen
tromethamine
multicomponent crystals
dissolution rate
solubility
Online Access:https://www.mdpi.com/2073-4352/12/2/275

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