Metastatic choriocarcinoma in the small bowel: a case report
cBackground: Choriocarcinoma is a highly malignant form of gestational trophoblastic disease. It is characterized by metastatic potential, rapid growth and deeply invasion into blood vessel and then widespread dissemination metastasis. However, the most common sites of metastatic choriocarcinoma are...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Tehran University of Medical Sciences
2014-08-01
|
| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5236&slc_lang=en&sid=1 |
| _version_ | 1819137571921330176 |
|---|---|
| author | Zohreh Yousefi Sedighe Ghasemian Mehrdizaj Mohamad Bidar Frimany Farzaneh Rashidi Fakari |
| author_facet | Zohreh Yousefi Sedighe Ghasemian Mehrdizaj Mohamad Bidar Frimany Farzaneh Rashidi Fakari |
| author_sort | Zohreh Yousefi |
| collection | DOAJ |
| description | cBackground: Choriocarcinoma is a highly malignant form of gestational trophoblastic disease. It is characterized by metastatic potential, rapid growth and deeply invasion into blood vessel and then widespread dissemination metastasis. However, the most common sites of metastatic choriocarcinoma are lung, vagina, liver, and brain. But, metastatic choriocarcinomas rarely is extended to gastrointestinal system. It is im-portant to keep in mind that despite extensive metastasis, choriocarcinoma is very curable disease. Due to high responsibility of this disease, early diagnosis of choriocarcinoma and treatment with chemotherapy can prevent mortality and morbidity of these patients. In this case report, we present a rare case of metastatic choriocarcinoma in the small bowel after normal term pregnancy.
Case Presentation: A 34-years-old woman G4, P4, L4 presented with abnormal postpar-tum vaginal bleeding (45 days) and unresponsive to usual medical and surgical therapy (oxytocine, metergene, antibiotic, and double curettage). The patient was admitted in the Ghaem Hospital, Mashhad University of Medical Sciences in April 2013. She suf-fered from rectal hemorrhage and severe weakness. Because of unsuitable condition (shock), laparotomy was performed and small bowel involvement was observed. Seg-mental resection of small bowel detected metastatic choriocarcinoma of the lesion. We couldn’t rescue our patient due to unresponsive to combination chemotherapy (actino-mycine, methotrexate, cyclophosfamide, vincrystine, etopuside).
Conclusion: In abnormal postpartum hemorrhage, we should consider the possibility of choriocarcinoma. Although, it is important to note rare manifestations of metastatic choriocarcinoma of small bowel in massive gastrointestinal hemorrhage. |
| first_indexed | 2024-12-22T10:53:00Z |
| format | Article |
| id | doaj.art-523a6eeabc3f4d3c94fa0f9e88e41645 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-22T10:53:00Z |
| publishDate | 2014-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-523a6eeabc3f4d3c94fa0f9e88e416452022-12-21T18:28:42ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222014-08-01725335339Metastatic choriocarcinoma in the small bowel: a case reportZohreh Yousefi 0Sedighe Ghasemian Mehrdizaj 1Mohamad Bidar Frimany 2Farzaneh Rashidi Fakari 3 Department of Gynecology On-cology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Clinical Patholo-gy, Mashhad, Iran. Department of Midwifery, Mash-had Faculty of Nursing and Mid-wifery, Mashhad University of Medical Sciences, Student Research Committee, Mashhad, Iran. cBackground: Choriocarcinoma is a highly malignant form of gestational trophoblastic disease. It is characterized by metastatic potential, rapid growth and deeply invasion into blood vessel and then widespread dissemination metastasis. However, the most common sites of metastatic choriocarcinoma are lung, vagina, liver, and brain. But, metastatic choriocarcinomas rarely is extended to gastrointestinal system. It is im-portant to keep in mind that despite extensive metastasis, choriocarcinoma is very curable disease. Due to high responsibility of this disease, early diagnosis of choriocarcinoma and treatment with chemotherapy can prevent mortality and morbidity of these patients. In this case report, we present a rare case of metastatic choriocarcinoma in the small bowel after normal term pregnancy. Case Presentation: A 34-years-old woman G4, P4, L4 presented with abnormal postpar-tum vaginal bleeding (45 days) and unresponsive to usual medical and surgical therapy (oxytocine, metergene, antibiotic, and double curettage). The patient was admitted in the Ghaem Hospital, Mashhad University of Medical Sciences in April 2013. She suf-fered from rectal hemorrhage and severe weakness. Because of unsuitable condition (shock), laparotomy was performed and small bowel involvement was observed. Seg-mental resection of small bowel detected metastatic choriocarcinoma of the lesion. We couldn’t rescue our patient due to unresponsive to combination chemotherapy (actino-mycine, methotrexate, cyclophosfamide, vincrystine, etopuside). Conclusion: In abnormal postpartum hemorrhage, we should consider the possibility of choriocarcinoma. Although, it is important to note rare manifestations of metastatic choriocarcinoma of small bowel in massive gastrointestinal hemorrhage.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5236&slc_lang=en&sid=1choriocarcinoma gestational trophoblastic disease metastasis postpartum hemorrhage small intestine |
| spellingShingle | Zohreh Yousefi Sedighe Ghasemian Mehrdizaj Mohamad Bidar Frimany Farzaneh Rashidi Fakari Metastatic choriocarcinoma in the small bowel: a case report Tehran University Medical Journal choriocarcinoma gestational trophoblastic disease metastasis postpartum hemorrhage small intestine |
| title | Metastatic choriocarcinoma in the small bowel: a case report |
| title_full | Metastatic choriocarcinoma in the small bowel: a case report |
| title_fullStr | Metastatic choriocarcinoma in the small bowel: a case report |
| title_full_unstemmed | Metastatic choriocarcinoma in the small bowel: a case report |
| title_short | Metastatic choriocarcinoma in the small bowel: a case report |
| title_sort | metastatic choriocarcinoma in the small bowel a case report |
| topic | choriocarcinoma gestational trophoblastic disease metastasis postpartum hemorrhage small intestine |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5236&slc_lang=en&sid=1 |
| work_keys_str_mv | AT zohrehyousefi metastaticchoriocarcinomainthesmallbowelacasereport AT sedigheghasemianmehrdizaj metastaticchoriocarcinomainthesmallbowelacasereport AT mohamadbidarfrimany metastaticchoriocarcinomainthesmallbowelacasereport AT farzanehrashidifakari metastaticchoriocarcinomainthesmallbowelacasereport |