Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer
Abstract Enteral nutrition has been reported to be safe and effective in malnourished patients undergoing upper gastrointestinal surgery. In this study, we devised night home enteral nutrition (N-HEN) as a novel nutritional strategy and evaluated the efficacy in gastric cancer patients following tot...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17420-8 |
| _version_ | 1798032549312724992 |
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| author | Shuhei Komatsu Tomoki Konishi Daiki Matsubara Koji Soga Katsumi Shimomura Jun Ikeda Fumihiro Taniguchi Hiroya Iwase Takeshi Kubota Yasuhiro Shioaki Eigo Otsuji |
| author_facet | Shuhei Komatsu Tomoki Konishi Daiki Matsubara Koji Soga Katsumi Shimomura Jun Ikeda Fumihiro Taniguchi Hiroya Iwase Takeshi Kubota Yasuhiro Shioaki Eigo Otsuji |
| author_sort | Shuhei Komatsu |
| collection | DOAJ |
| description | Abstract Enteral nutrition has been reported to be safe and effective in malnourished patients undergoing upper gastrointestinal surgery. In this study, we devised night home enteral nutrition (N-HEN) as a novel nutritional strategy and evaluated the efficacy in gastric cancer patients following total gastrectomy. Between January 2017 and March 2021, 24 patients were prospectively included in the protocol and supported by N-HEN for three postoperative months through a jejunostomy during the night (Elental:1200 kcal/day), and 22 patients without N-HEN were followed as a control group (CG). Body weight loss, nutritional indicators and tolerance to chemotherapy were evaluated. After 3 and 6 months, patients with N-HEN had significantly less body weight loss than CG (3 months P < 0.0001: N-HEN 4.0% vs. CG 15.2%, 6 months P < 0.0001: N-HEN 7.7% vs. CG 17.7%). Prealbumin was significantly higher in patients with N-HEN than CG after 3 and 6 months (3 months P < 0.0001, 6 months P = 0.0037). Albumin, total protein and hemoglobin, tended to be higher after 3 and 6 months in patients with N-HEN than CG, and total cholesterol after 6 months. Concerning the tolerance to adjuvant chemotherapy in Stage II–III patients, patients with N-HEN significantly had a higher completion rate (P = 0.0420: N-HEN 70% vs. CG 29%) and longer duration (P = 0.0313: N-HEN 458 days vs. CG 261 days) as planned. Continuous monitoring of blood glucose concentration in patients with N-HEN did not show nocturnal hypoglycemia or hyperglycemia. N-HEN could be a novel enforced and physiologically effective nutritional strategy to support potentially malnourished patients following total gastrectomy. |
| first_indexed | 2024-04-11T20:15:50Z |
| format | Article |
| id | doaj.art-523b27fa68a74efebe959eea440b7491 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T20:15:50Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-523b27fa68a74efebe959eea440b74912022-12-22T04:04:59ZengNature PortfolioScientific Reports2045-23222022-09-011211910.1038/s41598-022-17420-8Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancerShuhei Komatsu0Tomoki Konishi1Daiki Matsubara2Koji Soga3Katsumi Shimomura4Jun Ikeda5Fumihiro Taniguchi6Hiroya Iwase7Takeshi Kubota8Yasuhiro Shioaki9Eigo Otsuji10Department of Digestive Surgery (Gastric Surgery Division), Kyoto First Red Cross HospitalDepartment of Digestive Surgery (Gastric Surgery Division), Kyoto First Red Cross HospitalDepartment of Digestive Surgery (Gastric Surgery Division), Kyoto First Red Cross HospitalDepartment of Digestive Surgery (Gastric Surgery Division), Kyoto First Red Cross HospitalDepartment of Digestive Surgery (Gastric Surgery Division), Kyoto First Red Cross HospitalDepartment of Digestive Surgery (Gastric Surgery Division), Kyoto First Red Cross HospitalDepartment of Digestive Surgery (Gastric Surgery Division), Kyoto First Red Cross HospitalDepartment of Endocrinology and Metabolism, Kyoto First Red Cross HospitalDivision of Digestive Surgery (Gastric Surgery Division), Department of Surgery, Kyoto Prefectural University of MedicineDepartment of Digestive Surgery (Gastric Surgery Division), Kyoto First Red Cross HospitalDivision of Digestive Surgery (Gastric Surgery Division), Department of Surgery, Kyoto Prefectural University of MedicineAbstract Enteral nutrition has been reported to be safe and effective in malnourished patients undergoing upper gastrointestinal surgery. In this study, we devised night home enteral nutrition (N-HEN) as a novel nutritional strategy and evaluated the efficacy in gastric cancer patients following total gastrectomy. Between January 2017 and March 2021, 24 patients were prospectively included in the protocol and supported by N-HEN for three postoperative months through a jejunostomy during the night (Elental:1200 kcal/day), and 22 patients without N-HEN were followed as a control group (CG). Body weight loss, nutritional indicators and tolerance to chemotherapy were evaluated. After 3 and 6 months, patients with N-HEN had significantly less body weight loss than CG (3 months P < 0.0001: N-HEN 4.0% vs. CG 15.2%, 6 months P < 0.0001: N-HEN 7.7% vs. CG 17.7%). Prealbumin was significantly higher in patients with N-HEN than CG after 3 and 6 months (3 months P < 0.0001, 6 months P = 0.0037). Albumin, total protein and hemoglobin, tended to be higher after 3 and 6 months in patients with N-HEN than CG, and total cholesterol after 6 months. Concerning the tolerance to adjuvant chemotherapy in Stage II–III patients, patients with N-HEN significantly had a higher completion rate (P = 0.0420: N-HEN 70% vs. CG 29%) and longer duration (P = 0.0313: N-HEN 458 days vs. CG 261 days) as planned. Continuous monitoring of blood glucose concentration in patients with N-HEN did not show nocturnal hypoglycemia or hyperglycemia. N-HEN could be a novel enforced and physiologically effective nutritional strategy to support potentially malnourished patients following total gastrectomy.https://doi.org/10.1038/s41598-022-17420-8 |
| spellingShingle | Shuhei Komatsu Tomoki Konishi Daiki Matsubara Koji Soga Katsumi Shimomura Jun Ikeda Fumihiro Taniguchi Hiroya Iwase Takeshi Kubota Yasuhiro Shioaki Eigo Otsuji Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer Scientific Reports |
| title | Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer |
| title_full | Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer |
| title_fullStr | Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer |
| title_full_unstemmed | Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer |
| title_short | Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer |
| title_sort | night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer |
| url | https://doi.org/10.1038/s41598-022-17420-8 |
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