Shifting the Focus of Signaling Abnormalities in Colon Cancer
Colon cancer tumorigenesis occurs incrementally. The process involves the acquisition of mutations which typically follow an established pattern: activation of WNT signaling, activation of RAS signaling, and inhibition of TGF-β signaling. This arrangement recapitulates, to some degree, the stem cell...
Main Authors: | Markus A. Brown, Thomas Ried |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-02-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/14/3/784 |
Similar Items
-
Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma
by: Danijela Drakulic, et al.
Published: (2022-08-01) -
The scaffold protein AXIN1: gene ontology, signal network, and physiological function
by: Lu Qiu, et al.
Published: (2024-01-01) -
Keratin gene signature expression drives epithelial-mesenchymal transition through enhanced TGF-β signaling pathway activation and correlates with adverse prognosis in lung adenocarcinoma
by: Gang Li, et al.
Published: (2024-02-01) -
Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
by: Moon Jong Kim, et al.
Published: (2020-12-01) -
EFEMP1 binds to STEAP1 to promote osteosarcoma proliferation and invasion via the Wnt/β-catenin and TGF-β/Smad2/3 signal pathways
by: Dong Zhang, et al.
Published: (2022-12-01)