Disturbances of functional condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis
We have analyzed the results of experimental work of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, catalase) systems in guinea pigs’ lungs in experimental allergic alveolitis. The results of investigation showed that a significant...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2017-09-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/5232 |
| _version_ | 1818616943535456256 |
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| author | Mariana Ljubomurivna Baida |
| author_facet | Mariana Ljubomurivna Baida |
| author_sort | Mariana Ljubomurivna Baida |
| collection | DOAJ |
| description | We have analyzed the results of experimental work of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, catalase) systems in guinea pigs’ lungs in experimental allergic alveolitis. The results of investigation showed that a significant increase in conjugated diene level in animals’ lungs was observed at all stages of experimental allergic alveolitis development under the conditions of immobilization stress as compared with control group, indicating activation of this marker.
The same changes occurred with malondialdehyde content, indicating excessive accumulation of this lipid peroxidation product in lung tissue. Oxygen-derived free radicals produced by phagocytes are believed to contribute to lung tissue damage. A lung defence mechanism against oxidative stress produces antioxidant molecules. In the early period of experiment (24th, 34th days) compensatory increasing superoxide dismutase and catalase in the lungs of guinea pigs has been reported. Late period of this pathology (44 th, 54 th days) was accompanied with reduction of these antioxidant enzymes. Increased oxidant levels and decreased antioxidant defences can contribute to the progression of experimental allergic alveolitis. |
| first_indexed | 2024-12-16T16:57:50Z |
| format | Article |
| id | doaj.art-523cf8d9e98542cdbdeae0e52f3daf18 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-16T16:57:50Z |
| publishDate | 2017-09-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-523cf8d9e98542cdbdeae0e52f3daf182022-12-21T22:23:50ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062017-09-017963664210.5281/zenodo.11627904879Disturbances of functional condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitisMariana Ljubomurivna Baida0Danylo Halytsky Lviv National Medical UniversityWe have analyzed the results of experimental work of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, catalase) systems in guinea pigs’ lungs in experimental allergic alveolitis. The results of investigation showed that a significant increase in conjugated diene level in animals’ lungs was observed at all stages of experimental allergic alveolitis development under the conditions of immobilization stress as compared with control group, indicating activation of this marker. The same changes occurred with malondialdehyde content, indicating excessive accumulation of this lipid peroxidation product in lung tissue. Oxygen-derived free radicals produced by phagocytes are believed to contribute to lung tissue damage. A lung defence mechanism against oxidative stress produces antioxidant molecules. In the early period of experiment (24th, 34th days) compensatory increasing superoxide dismutase and catalase in the lungs of guinea pigs has been reported. Late period of this pathology (44 th, 54 th days) was accompanied with reduction of these antioxidant enzymes. Increased oxidant levels and decreased antioxidant defences can contribute to the progression of experimental allergic alveolitis.http://www.ojs.ukw.edu.pl/index.php/johs/article/view/5232experimental allergic alveolitis, peroxide lipid oxidation, antioxidant system |
| spellingShingle | Mariana Ljubomurivna Baida Disturbances of functional condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis Journal of Education, Health and Sport experimental allergic alveolitis, peroxide lipid oxidation, antioxidant system |
| title | Disturbances of functional condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis |
| title_full | Disturbances of functional condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis |
| title_fullStr | Disturbances of functional condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis |
| title_full_unstemmed | Disturbances of functional condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis |
| title_short | Disturbances of functional condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis |
| title_sort | disturbances of functional condition of pro oxidant and antioxidant systems in guinea pigs lungs in experimental allergic alveolitis |
| topic | experimental allergic alveolitis, peroxide lipid oxidation, antioxidant system |
| url | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/5232 |
| work_keys_str_mv | AT marianaljubomurivnabaida disturbancesoffunctionalconditionofprooxidantandantioxidantsystemsinguineapigslungsinexperimentalallergicalveolitis |