Echocardiographic characteristics of dogs with pulmonary hypertension secondary to respiratory diseases
Abstract Background Pulmonary hypertension (PH) secondary to respiratory disease is caused by pulmonary vascular remodeling and hypoxia. Severe PH can induce various clinical signs, including syncope and right‐sided heart failure. Hypothesis/Objectives To investigate the echocardiographic characteri...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16836 |
| _version_ | 1827854447916613632 |
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| author | Yunosuke Yuchi Ryohei Suzuki Takahiro Saito Yuyo Yasumura Takahiro Teshima Hirotaka Matsumoto Hidekazu Koyama |
| author_facet | Yunosuke Yuchi Ryohei Suzuki Takahiro Saito Yuyo Yasumura Takahiro Teshima Hirotaka Matsumoto Hidekazu Koyama |
| author_sort | Yunosuke Yuchi |
| collection | DOAJ |
| description | Abstract Background Pulmonary hypertension (PH) secondary to respiratory disease is caused by pulmonary vascular remodeling and hypoxia. Severe PH can induce various clinical signs, including syncope and right‐sided heart failure. Hypothesis/Objectives To investigate the echocardiographic characteristics in dogs with PH secondary to respiratory diseases. Animals Thirty‐one dogs with respiratory diseases with or without PH and 15 healthy dogs. Methods Prospective cross‐sectional study. Dogs were classified according to respiratory disease (obstructive airway/lung disease [OALD] or restrictive lung disease [RLD]) and PH‐relevant signs. The association between echocardiographic variables and PH (classified by respiratory disease and PH‐relevant signs) was investigated. Results Twenty‐one dogs were diagnosed with PH; of these, 11 showed PH‐related signs (OALD, n = 2; RLD, n = 9), 14 had right ventricular hypertrophy, and 19 had pulmonary arterial enlargement. Right ventricular dysfunction and dilatation were observed only in dogs with PH‐related signs (n = 10). Left and right ventricular stroke volumes were significantly lower in dogs with PH (median [interquartile range]: 17.2 [12.4‐20.8] and 16.8 [15.3‐29.5] mL/m2, respectively). Dogs with RLD had higher echocardiography‐estimated pulmonary vascular resistance than those with OALD (median [interquartile range]: 3.1 [1.9‐3.3] and 1.6 [1.3‐2.2], respectively). Conclusions and Clinical Importance Pulmonary arterial enlargement was the most common echocardiographic finding in dogs with PH secondary to respiratory diseases. Right ventricular dysfunction, dilatation, and decreased left and right ventricular stroke volume were significantly associated with the PH‐related signs, indicating that comprehensive echocardiography is recommended in dogs with respiratory disease. Restricted lung disease might induce more severe PH than OALD. |
| first_indexed | 2024-03-12T11:22:53Z |
| format | Article |
| id | doaj.art-523d4c0161e249ec970dcc3003a7045f |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-03-12T11:22:53Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-523d4c0161e249ec970dcc3003a7045f2023-09-01T14:18:40ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762023-09-013751656166610.1111/jvim.16836Echocardiographic characteristics of dogs with pulmonary hypertension secondary to respiratory diseasesYunosuke Yuchi0Ryohei Suzuki1Takahiro Saito2Yuyo Yasumura3Takahiro Teshima4Hirotaka Matsumoto5Hidekazu Koyama6Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science Nippon Veterinary and Life Science University Tokyo JapanLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science Nippon Veterinary and Life Science University Tokyo JapanLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science Nippon Veterinary and Life Science University Tokyo JapanLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science Nippon Veterinary and Life Science University Tokyo JapanLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science Nippon Veterinary and Life Science University Tokyo JapanLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science Nippon Veterinary and Life Science University Tokyo JapanLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science Nippon Veterinary and Life Science University Tokyo JapanAbstract Background Pulmonary hypertension (PH) secondary to respiratory disease is caused by pulmonary vascular remodeling and hypoxia. Severe PH can induce various clinical signs, including syncope and right‐sided heart failure. Hypothesis/Objectives To investigate the echocardiographic characteristics in dogs with PH secondary to respiratory diseases. Animals Thirty‐one dogs with respiratory diseases with or without PH and 15 healthy dogs. Methods Prospective cross‐sectional study. Dogs were classified according to respiratory disease (obstructive airway/lung disease [OALD] or restrictive lung disease [RLD]) and PH‐relevant signs. The association between echocardiographic variables and PH (classified by respiratory disease and PH‐relevant signs) was investigated. Results Twenty‐one dogs were diagnosed with PH; of these, 11 showed PH‐related signs (OALD, n = 2; RLD, n = 9), 14 had right ventricular hypertrophy, and 19 had pulmonary arterial enlargement. Right ventricular dysfunction and dilatation were observed only in dogs with PH‐related signs (n = 10). Left and right ventricular stroke volumes were significantly lower in dogs with PH (median [interquartile range]: 17.2 [12.4‐20.8] and 16.8 [15.3‐29.5] mL/m2, respectively). Dogs with RLD had higher echocardiography‐estimated pulmonary vascular resistance than those with OALD (median [interquartile range]: 3.1 [1.9‐3.3] and 1.6 [1.3‐2.2], respectively). Conclusions and Clinical Importance Pulmonary arterial enlargement was the most common echocardiographic finding in dogs with PH secondary to respiratory diseases. Right ventricular dysfunction, dilatation, and decreased left and right ventricular stroke volume were significantly associated with the PH‐related signs, indicating that comprehensive echocardiography is recommended in dogs with respiratory disease. Restricted lung disease might induce more severe PH than OALD.https://doi.org/10.1111/jvim.16836caninemyocardial strainobstructive airway/lung diseaserestrictive lung diseaseright heart failurespeckle tracking echocardiography |
| spellingShingle | Yunosuke Yuchi Ryohei Suzuki Takahiro Saito Yuyo Yasumura Takahiro Teshima Hirotaka Matsumoto Hidekazu Koyama Echocardiographic characteristics of dogs with pulmonary hypertension secondary to respiratory diseases Journal of Veterinary Internal Medicine canine myocardial strain obstructive airway/lung disease restrictive lung disease right heart failure speckle tracking echocardiography |
| title | Echocardiographic characteristics of dogs with pulmonary hypertension secondary to respiratory diseases |
| title_full | Echocardiographic characteristics of dogs with pulmonary hypertension secondary to respiratory diseases |
| title_fullStr | Echocardiographic characteristics of dogs with pulmonary hypertension secondary to respiratory diseases |
| title_full_unstemmed | Echocardiographic characteristics of dogs with pulmonary hypertension secondary to respiratory diseases |
| title_short | Echocardiographic characteristics of dogs with pulmonary hypertension secondary to respiratory diseases |
| title_sort | echocardiographic characteristics of dogs with pulmonary hypertension secondary to respiratory diseases |
| topic | canine myocardial strain obstructive airway/lung disease restrictive lung disease right heart failure speckle tracking echocardiography |
| url | https://doi.org/10.1111/jvim.16836 |
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